{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:39:43Z","timestamp":1770989983149,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ketogenic diet (KD) is a low\u2010carbohydrate, high\u2010fat diet that has been used as an effective nonpharmacological treatment in many neurological and metabolic disorders for a long time. The effectiveness of the KD is revealed in mitochondrial disorders, mainly in pyruvate dehydrogenase deficiency.<\/jats:p><jats:p>Case report: A 4\u2010year\u2010old girl who was diagnosed with an F\u2010box and leucine\u2010rich repeat protein 4 (<jats:italic>FBXL4<\/jats:italic>) gene mutation was hospitalized with sepsis. She was first given standard parenteral nutrition (PN) because of gastrointestinal problems. During the disease course, lactic acidosis became prominent and did not respond to pharmacological treatment; standard PN was gradually switched to parenteral KD, and lactate levels decreased after parenteral KD. The patient was discharged with an enteral KD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first case of mitochondrial depletion syndrome effectively treated with parenteral KD for lactic acidosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2121","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:55:44Z","timestamp":1619052944000},"page":"1788-1792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The first case with <i>FBXL4<\/i> mutation successfully treated with a parenteral ketogenic diet for lactic acidosis"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5446-4140","authenticated-orcid":false,"given":"Asl\u0131","family":"\u0130nci","sequence":"first","affiliation":[{"name":"Department of Pediatric Metabolism and Nutrition Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism and Nutrition Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiz Ba\u015fak","family":"Cengiz Ergin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism and Nutrition Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lyas","family":"Okur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism and Nutrition Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcrsel","family":"Bibero\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism and Nutrition Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih S\u00fcheyl","family":"Ezg\u00fc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism and Nutrition Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyla","family":"T\u00fcmer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism and Nutrition Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.02066.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.01.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12591"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20899"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04704.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1102"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12646"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-016-0011-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.6.1655"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.2121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpen.2121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.2121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:52:16Z","timestamp":1760871136000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.2121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/jpen.2121"],"URL":"https:\/\/doi.org\/10.1002\/jpen.2121","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]},"assertion":[{"value":"2021-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}