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The current manuscript presents the case of a 74\u2010year\u2010old male with obesity complicated by coronary artery disease, hypertriglyceridemia, hypertension, nonalcoholic fatty liver disease, obstructive sleep apnea, and type 2 diabetes. Expert panelists discuss optimal diagnostic and treatment strategies focused on lifestyle modifications including dietary interventions such as the Mediterranean dietary pattern, medications that target multiple drivers of disease, as well as procedural options.<\/jats:p>","DOI":"10.1002\/jpen.2219","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T04:15:01Z","timestamp":1639368901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case presentation and panel discussion: Cardiometabolic risk mitigation"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-3544","authenticated-orcid":false,"given":"Manpreet S.","family":"Mundi","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-588X","authenticated-orcid":false,"given":"Jeffrey I.","family":"Mechanick","sequence":"additional","affiliation":[{"name":"Kravis Center for Clinical Cardiovascular Health at Mount Sinai Heart Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-7670","authenticated-orcid":false,"given":"Jayshil J.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Al\u2010Kazaz","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart Institute Icahn School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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