{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:16:08Z","timestamp":1769591768660,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to determine whether human milk supplemented with a novel human milk\u2013based human milk fortifier (Novel HMF), compared with a bovine milk\u2013based HMF (Bovine HMF), supports preterm infant growth through 36 weeks\u2019 postmenstrual age (PMA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center, prospective trial compared growth and nutrition outcomes of preterm infants provided a human milk\u2013based diet (mother's own milk or donor milk) supplemented with a Novel HMF with historic controls provided Bovine HMF. Preterm infants with an estimated gestational age (EGA) between 23 and 33 weeks\u2019 PMA and birth weight between 750 and 1800 g were eligible for study inclusion. Weight, length, and head circumference (HC) were monitored weekly. The occurrence of late\u2010onset sepsis, nil per os (NPO) days, necrotizing enterocolitis, metabolic acidosis, and serious adverse events were monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Birth weight, length, HC, and EGA were similar between the Novel HMF (n = 37) and Bovine HMF (n = 49) groups. The days to regain birth weight was shorter in the Novel HMF group (9.4 \u00b1 4.0 vs 11.4 \u00b1 4.8, <jats:italic>P<\/jats:italic> = .0343), with similar weight gain (g\/day) from birth to 36 weeks\u2019 PMA. Adjusted weight growth velocity (g\/kg\/day) was significantly higher in the Novel HMF group at 14 and 21 days but similar at 36 weeks\u2019 PMA. The Novel HMF group experienced fewer NPO days with a similar total number of feeding days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A novel, multinutrient, human milk\u2013based HMF is well tolerated and meets the nutrition needs of preterm infants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2249","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T15:48:34Z","timestamp":1628524114000},"page":"818-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel multinutrient human milk\u2010based human milk fortifier promotes growth and tolerance in premature infants"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-543X","authenticated-orcid":false,"given":"Amy","family":"Gates","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri","family":"Marin","sequence":"additional","affiliation":[{"name":"College of Nursing Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Waller","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Data Science, Department of Population Health Sciences, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-8895","authenticated-orcid":false,"given":"Brian K.","family":"Stansfield","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.10.040"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.07.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-188"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.05.341"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.10126"},{"issue":"7","key":"e_1_2_8_8_1","article-title":"Formula versus donor breast milk for feeding preterm or low birth weight infants","volume":"7","author":"Quigley M","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.117"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01024-7"},{"issue":"3","key":"e_1_2_8_11_1","first-page":"e827","article-title":"Breastfeeding and the use of human milk","volume":"123","year":"2012","journal-title":"Pediatrics"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10570"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351537"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.09.008"},{"key":"e_1_2_8_15_1","first-page":"297","volume-title":"Nutritional Care of Preterm Infants. 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