{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:32Z","timestamp":1786978112264,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T00:00:00Z","timestamp":1646524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Feeding intolerance (FI) is a common clinical problem in preterm infants often caused by some neonatal disorders and drugs, including antenatal exposure to magnesium sulfate (MgSO\n                      <jats:sub>4<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between hypermagnesemia at birth and FI in preterm infants during the first 72\u2009h of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This was a cohort study conducted with preterm infants aged &lt;34 weeks' gestation. Infants presenting at least two of the following signs were considered as having FI: vomiting, abdominal distension, the need for continuous intermittent feeding, and delayed meconium passage. Hypermagnesemia was characterized by umbilical serum Mg levels\u2009&gt;\u20092.5\u2009mEq\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total 251 infants were evaluated. The median birth weight and gestational age were 1390\u2009g (IQR, 1020\u20131070) and 31 weeks (IQR, 28\u201332). The FI rate was 17.5%. The exposure rate to MgSO\n                      <jats:sub>4<\/jats:sub>\n                      was similar in the tolerant and intolerant groups (53.1%\u2009\u00d7\u200963.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.204), but hypermagnesemia was more frequent in the FI group (40.9%\u2009\u00d7\u200924.2%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.024). The univariate analysis showed that infants with hypermagnesemia were twofold more likely to present FI (odds ratio [OR], 2.16; 95% CI, 1.09\u20134.26). In the multiple logistic regression analysis, we found that hypermagnesemia was independently associated with FI (OR, 2.51; 95% CI, 1.06\u20135.91), as well as maternal diabetes mellitus (OR, 2.56; 95% CI, 1.07\u20136.14), Score for Neonatal Acute Physiology\u2010Perinatal Extension II (OR, 1.051; 95% CI, 1.025\u20131.078), and brain hemorrhage (OR, 3.61; 95% CI, 1.31\u20139.91).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In addition to other factors, hypermagnesemia at birth was independently associated with early FI in preterm infants.<\/jats:p>\n                  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