{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:41:31Z","timestamp":1791319291078,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Apraglutide is a novel long\u2010acting glucagon\u2010like peptide\u20102 (GLP\u20102) analog designed for once\u2010weekly subcutaneous dosing, with the potential to increase fluid and nutrient absorption by the remnant intestine of patients who have short bowel syndrome (SBS) with intestinal insufficiency (SBS\u2010II) or intestinal failure (SBS\u2010IF). This trial investigated the safety and effects on intestinal absorption of apraglutide in patients with SBS\u2010II and SBS\u2010IF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this open\u2010label, phase 1 and 2 trial, adult patients with SBS\u2010II (<jats:italic>n<\/jats:italic>\u2009=\u20094) or SBS\u2010IF (<jats:italic>n<\/jats:italic>\u2009=\u20094) and a fecal output of \u22651500\u2009g\/day received once\u2010weekly subcutaneous 5\u2009mg apraglutide for 4 weeks. Safety was the primary end point. Secondary end points included change from baseline in intestinal absorption of wet weight (indicative of fluid absorption), electrolytes, and energy (by bomb calorimetry) measured by inpatient metabolic balance studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Common treatment\u2010related adverse events were decreased gastrointestinal (GI) stoma output (<jats:italic>n<\/jats:italic>\u2009=\u20096), stoma complications (<jats:italic>n<\/jats:italic>\u2009=\u20096), GI stoma complications (<jats:italic>n<\/jats:italic>\u2009=\u20095), nausea (<jats:italic>n<\/jats:italic>\u2009=\u20095), flatulence (<jats:italic>n<\/jats:italic>\u2009=\u20094), abnormal GI stoma output (<jats:italic>n<\/jats:italic>\u2009=\u20094), polyuria (<jats:italic>n<\/jats:italic>\u2009=\u20093), and abdominal pain (<jats:italic>n<\/jats:italic>\u2009=\u20093). The only treatment\u2010related serious adverse event (experienced in one patient) was abdominal pain. Apraglutide significantly increased wet weight and energy absorption by an adjusted mean of 741\u2009g\/day (95% CI, 194 to 1287; <jats:italic>P<\/jats:italic>\u2009=\u20090.015) and 1095\u2009kJ\/day (95% CI, 196 to 1994; <jats:italic>P<\/jats:italic>\u2009=\u20090.024), respectively. Sodium and potassium absorption significantly increased by an adjusted mean of 38\u2009mmol\/day (95% CI, 3 to 74; <jats:italic>P<\/jats:italic>\u2009=\u20090.039) and 18\u2009mmol\/day (95% CI, 4 to 32; <jats:italic>P<\/jats:italic>\u2009=\u20090.020), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Once\u2010weekly 5\u2009mg apraglutide was well tolerated in patients with SBS\u2010II and SBS\u2010IF and significantly improved the absorption of fluids, electrolytes, and energy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2362","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:38:56Z","timestamp":1646181536000},"page":"1639-1649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Apraglutide, a novel once\u2010weekly glucagon\u2010like peptide\u20102 analog, improves intestinal fluid and energy absorption in patients with short bowel syndrome: An open\u2010label phase 1 and 2 metabolic balance trial"],"prefix":"10.1002","volume":"46","author":[{"given":"Johanna","family":"Eliasson","sequence":"first","affiliation":[{"name":"Department of Intestinal Failure and Liver Diseases Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Hvistendahl","sequence":"additional","affiliation":[{"name":"Department of Intestinal Failure and Liver Diseases Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna","family":"Freund","sequence":"additional","affiliation":[{"name":"Department of Intestinal Failure and Liver Diseases Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bolognani","sequence":"additional","affiliation":[{"name":"VectivBio AG Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Meyer","sequence":"additional","affiliation":[{"name":"VectivBio AG Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9680-6938","authenticated-orcid":false,"given":"Palle B.","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Intestinal Failure and Liver Diseases Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05779-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.061440"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.218271"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1588"},{"key":"e_1_2_8_7_1","unstructured":"US Food and Drug Administration. Prescribing information. Gattex. Revised December 2012. Accessed February 2021.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/203441Orig1s000lbl.pdf"},{"key":"e_1_2_8_8_1","unstructured":"European Medicines Agency. Summary of product characteristics. Revestive. Updated May 2017. Accessed February 2021.https:\/\/www.ema.europa.eu\/en\/documents\/overview\/revestive-epar-summary-public_en.pdf"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008320605"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009342252"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.9.1171"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.4.559"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171486"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1767"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.7.5840"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2011.03.003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.165886"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.1.112"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114520994"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.08.017"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617734788"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10471"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15432"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31823d0ec5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(03)00042-6"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802078325"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.6.844"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.01.028"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70388-4"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6918(03)00079-9"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2020.09.035"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.262238"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01909"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1853"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.263947"},{"issue":"3","key":"e_1_2_8_36_1","first-page":"238","article-title":"Intestinal insufficiency and failure","volume":"50","author":"Jeppesen PB","year":"2003","journal-title":"Dan Med Bull"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(21)02476-8"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.6.763"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20227"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30077-9"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22555"},{"key":"e_1_2_8_42_1","doi-asserted-by":"crossref","unstructured":"EliassonJ HvistendahlMK FreundN BolognaniF MeyerC JeppesenPB.Apraglutide a novel glucagon\u2010like peptide\u20102 analog improves fluid absorption in patients with short bowel syndrome intestinal failure: findings from a placebo\u2010controlled randomized phase 2 trial.JPEN J Parenter Enteral Nutr.2021.","DOI":"10.1002\/jpen.2223"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.69"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.274.5.E808"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.158386"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.023"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617737632"},{"key":"e_1_2_8_48_1","unstructured":"Takeda. Medication Guide. GATTEX\u00ae (teduglutide). January 2021. Accessed March 2022.https:\/\/www.shirecontent.com\/MEDGUIDE\/PDFs\/MG_Gattex_USA_ENG.pdf"},{"key":"e_1_2_8_49_1","first-page":"616054","article-title":"Short bowel patients treated for two years with glucagon\u2010like Peptide 2: effects on intestinal morphology and absorption, renal function, bone and body composition, and muscle function","volume":"2009","author":"Jeppesen PB","year":"2009","journal-title":"Gastroenterol Res Pract"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.2362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpen.2362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.2362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:40:47Z","timestamp":1760866847000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.2362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,28]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/jpen.2362"],"URL":"https:\/\/doi.org\/10.1002\/jpen.2362","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,28]]},"assertion":[{"value":"2022-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}