{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:33:59Z","timestamp":1778614439411,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T00:00:00Z","timestamp":1651968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aim to assess whether the docosahexaenoic acid (DHA)\u2013containing lipid emulsion (LE) SMOFlipid 20% (Fresenius Kabi Canada Ltd) is associated with bronchopulmonary dysplasia (BPD)\u2013free survival at 36 weeks' postmenstrual age in very preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study is nested in the MOBYDIck randomized clinical trial (NCT02371460), which investigated the effect of maternal DHA supplementation on BPD\u2010free survival in breastfed very preterm infants born between 23 0\/7 and 28 6\/7 weeks' gestation in 16 Canadian neonatal intensive care units (2015\u20132018). Parenteral SMOF\u2010LE was given to the infants according to the sites' routine care protocols. Relative risks (RRs) were estimated using a modified Poisson regression model with generalized estimating equations taking into account recruitment site, multiple birth, DHA supplementation, birth weight, sex, and gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 528 infants (mean gestational age, 26.5 weeks [SD, 1.6]), 272 received SMOF\u2010LE. Overall, 56.7% of the infants in the SMOF\u2010LE group and 59.7% infants in the non\u2013SMOF\u2010LE group survived without BPD (adjusted RR, 0.94 [95% CI, 0.77\u20131.14]; <jats:italic>P<\/jats:italic>\u2009=\u20090.51). BPD rates were 39.3% in the SMOF\u2010LE group vs 34.1% in the non\u2013SMOF\u2010LE group (adjusted RR, 1.10 [95% CI, 0.82\u20131.47]; <jats:italic>P<\/jats:italic>\u2009=\u20090.53). Severe BPD rates were 31.8% in the SMOF\u2010LE group vs 28.8% in the non\u2013SMOF\u2010LE group (adjusted <jats:italic>P<\/jats:italic>\u2009=\u20090.59). Mortality was not significantly different between the SMOF\u2010LE (6.7%) and non\u2013SMOF\u2010LE groups (9.5%; adjusted <jats:italic>P<\/jats:italic>\u2009=\u20090.40).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In very preterm infants, intravenous DHA\u2010containing SMOF\u2010LE during the neonatal period was not associated with BPD\u2010free survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2380","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T03:13:14Z","timestamp":1649646794000},"page":"1892-1902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Use of SMOF lipid emulsion in very preterm infants does not affect the incidence of bronchopulmonary dysplasia\u2013free survival"],"prefix":"10.1002","volume":"46","author":[{"given":"Aissatou B.K.T.","family":"Ndiaye","sequence":"first","affiliation":[{"name":"Department of Pediatrics CHU de Que\u0301bec\u2010Universite\u0301  Laval Que\u0301bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universite\u0301 de Montre\u0301al, CHU Sainte\u2010Justine  Montre\u0301al Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-9546","authenticated-orcid":false,"given":"Etienne","family":"Pronovost","sequence":"additional","affiliation":[{"name":"Department of Pediatrics CHU de Que\u0301bec\u2010Universite\u0301  Laval Que\u0301bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Angoa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics CHU de Que\u0301bec\u2010Universite\u0301  Laval Que\u0301bec 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