{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:27:57Z","timestamp":1785252477255,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012412","name":"Kansai Medical University","doi-asserted-by":"publisher","award":["Research grant D2"],"award-info":[{"award-number":["Research grant D2"]}],"id":[{"id":"10.13039\/501100012412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with severe motor and intellectual disabilities (SMIDs) frequently and continuously receive enteral nutrition and medications and lack adequate exercise, which may lead to dysbiosis, an imbalance in the composition of the gut microbiota. However, studies on the composition of gut microbiota in children with SMIDs are limited. Therefore, we aimed to examine the characteristics of the gut microbiota in children with SMIDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>16S rRNA gene sequencing was performed using fecal samples of 10 children with SMIDs, who received enteral nutrition through a gastric fistula or gastric tube (SMID group: median age, 10.0 years), and 19 healthy children (healthy control [HC] group: median age, 9.0 years). Microbial diversity, microbial composition, and abundance of butyric acid\u2010producing bacteria were compared between the groups. Daily dietary fiber intake in the SMID group was evaluated using questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Shannon and Simpson indices (alpha diversity indices) were significantly lower in the SMID group than those in the HC group. Beta diversity analysis identified different clusters. Compared with the HC group, Clostridiales and butyric acid\u2010producing bacteria were less abundant and Bacteroidales were more abundant in the SMID group. Dietary fiber intake in the SMID group was approximately two\u2010thirds of the estimated average requirement for healthy Japanese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with SMIDs showed dysbiosis with alteration in the microbial diversity, which could partly be attributed to their low dietary fiber intake. Further studies, with the intervention of prebiotics, probiotics, and synbiotics, are warranted to improve dysbiosis in children with SMIDs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2435","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T04:29:30Z","timestamp":1658982570000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dysbiosis of the gut microbiota in children with severe motor and intellectual disabilities receiving enteral nutrition: A pilot study"],"prefix":"10.1002","volume":"47","author":[{"given":"Yoko","family":"Nakai","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1659-4187","authenticated-orcid":false,"given":"Shohei","family":"Akagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadayuki","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0344-7778","authenticated-orcid":false,"given":"Yuko","family":"Akagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohsaku","family":"Yamanouchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Kimata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Hashiyada","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Akane","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3607-8355","authenticated-orcid":false,"given":"Shoji","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8215-0832","authenticated-orcid":false,"given":"Kazunari","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12938\/bmfh.2020-034"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2824"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.01.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30278-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-017-1445-8"},{"issue":"11","key":"e_1_2_10_8_1","first-page":"648","article-title":"Basic issue on severe motor and intellectual disabilities","volume":"35","author":"Oshima K","year":"1971","journal-title":"Nippon Koshu Eisei Zasshi"},{"key":"e_1_2_10_9_1","unstructured":"Ministry of Health Labour and Welfare.Overview of the dietary reference intakes for Japanese (2020). 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