{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:33:30Z","timestamp":1784640810993,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intestinal failure\u2013associated liver disease (IFALD), initially manifesting as cholestasis, is a complication in neonates receiving parenteral nutrition (PN). Soybean oil lipid emulsion (SOLE), though implicated in IFALD, was the only US Food and Drug Administration (FDA)\u2013approved initial intravenous lipid emulsion (ILE) for infants and children in the United States. A mixed\u2010oil lipid emulsion (MOLE) gained popularity in patients at risk for IFALD and was recently FDA approved as an initial ILE in children. Given the presence of soybean oil in MOLE, we hypothesized that MOLE would not be effective at preventing cholestasis in surgical neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Neonates with gastrointestinal surgical conditions necessitating PN for \u226514 days and receiving MOLE (SMOFlipid) from July 2016 to July 2019 were analyzed retrospectively. Unpaired and pair\u2010matched historical surgical neonates treated with SOLE (Intralipid) served as controls. The primary outcome measure was development of cholestasis (direct bilirubin \u22652\u2009mg\/dl).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 63% (10 of 16) of MOLE patients and 22% (30 of 136) of SOLE patients developed cholestasis after \u226514 days of therapy (<jats:italic>P<\/jats:italic>\u2009=\u20090.005). The latency to developing cholestasis was significantly shorter in MOLE patients compared with SOLE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In surgical neonates, MOLE may not prevent cholestasis and should not be considered hepatoprotective. Regardless of ILE source, all surgical neonates should be closely monitored for development of IFALD. To date, there is still no ILE able to prevent IFALD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2458","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T08:57:47Z","timestamp":1667033867000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Incidence and development of cholestasis in surgical neonates receiving an intravenous mixed\u2010oil lipid emulsion"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0370-4444","authenticated-orcid":false,"given":"Lumeng J.","family":"Yu","sequence":"first","affiliation":[{"name":"Vascular Biology Program and Department of Surgery, Boston Children's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Anez\u2010Bustillos","sequence":"additional","affiliation":[{"name":"Vascular Biology Program and Department of Surgery, Boston Children's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Institutional Centers for Clinical and Translational Research Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria H.","family":"Ko","sequence":"additional","affiliation":[{"name":"Vascular Biology Program and Department of Surgery, Boston Children's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan D.","family":"Secor","sequence":"additional","affiliation":[{"name":"Vascular Biology Program and Department of Surgery, Boston Children's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savas T.","family":"Tsikis","sequence":"additional","affiliation":[{"name":"Vascular Biology Program and Department of Surgery, Boston Children's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0431-896X","authenticated-orcid":false,"given":"Kathleen M.","family":"Gura","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-2926","authenticated-orcid":false,"given":"Mark","family":"Puder","sequence":"additional","affiliation":[{"name":"Vascular Biology Program and Department of Surgery, Boston Children's Hospital Harvard Medical School Boston Massachusetts 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