{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:29:24Z","timestamp":1760920164125,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most data on anemia in children with intestinal failure (IF) have been obtained from studies in which the data were collected at a single point in time. We aimed to identify the frequency of anemia and factors associated with hemoglobin levels in children with IF during their course of home parenteral nutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a longitudinal cohort study of patients with IF followed up at a pediatric intestinal rehabilitation center. Outcome variables were hemoglobin levels and prevalence of anemia during the follow\u2010up period. The exposure variables were age, duration of parenteral nutrition, chronic disease, and serum concentrations of C\u2010reactive protein, iron, copper, selenium, vitamins A, D, B<jats:sub>12<\/jats:sub>, and folic acid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five children with a median time of receiving parenteral nutrition of 40.7 months were included. A median (and interquartile range) of 40.7 (25.2\u201358) hemoglobin measurements were performed per patient. Mean (SD) hemoglobin was 10.7 (1.8)\u2009g\/dL at baseline and 11.6 (0.9)\u2009g\/dL in the last observation (paired <jats:italic>t<\/jats:italic> test, <jats:italic>P<\/jats:italic>\u2009=\u20090.07); 32% of patients had mean hemoglobin values below the lower limit for age. In a multivariable predictive model, having C\u2010reactive protein &gt;1\u2009mg\/dL was associated with a decrease of 0.57\u2009g\/dL in hemoglobin (95% CI, \u22120.90 to \u22120.24, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), and an increase of 1\u2009mg\/L in vitamin A concentration was associated with the increase of 0.93\u2009g\/dL in Hb level (95% CI, 0.24\u20131.61; <jats:italic>P<\/jats:italic>\u2009=\u20090.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anemia affects almost one\u2010third of children with IF and its frequency decreases during the follow\u2010up period. Hemoglobin levels are associated with inflammatory response and serum micronutrient concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2478","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T22:29:27Z","timestamp":1674253767000},"page":"382-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation and micronutrient deficiency as major risk factors for anemia in children with intestinal failure:\u00a0A longitudinal cohort study"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8260-7559","authenticated-orcid":false,"given":"Heitor P.","family":"Leite","sequence":"first","affiliation":[{"name":"Center for Intestinal Rehabilitation Hospital Samaritano de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Pediatrics Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo F.","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Center for Intestinal Rehabilitation Hospital Samaritano de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Pediatrics Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovana S.","family":"Galati Sabio","sequence":"additional","affiliation":[{"name":"Center for Intestinal Rehabilitation Hospital Samaritano de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria F.","family":"Carvalho de Camargo","sequence":"additional","affiliation":[{"name":"Center for Intestinal Rehabilitation Hospital Samaritano de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.12.049"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.07.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-856500"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1804281"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-020-00404-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.02.039"},{"key":"e_1_2_8_9_1","unstructured":"UpToDate.Normal values for hematologic parameters in children.2022.https:\/\/www.uptodate.com\/contents\/image?imageKey=PEDS%2F101544#!"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000586"},{"key":"e_1_2_8_11_1","unstructured":"GuraK ElisofonS.Intestinal failure\u2010associated liver disease in infants. 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