{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:58:56Z","timestamp":1784638736875,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T00:00:00Z","timestamp":1678579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intestinal failure\u2013associated liver disease (IFALD) occurs in up to 50% of neonates treated with prolonged parenteral nutrition. Preventative strategies for IFALD include soybean oil lipid emulsion (SOLE) minimization and use of mixed\u2010oil intravenous lipid emulsions (ILE). We conducted a pilot study prospectively comparing these two ILE strategies in the prevention of IFALD in neonates who required abdominal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We randomized eligible neonates to SOLE at 1\u2009g\/kg\/day (SOLE Min) or mixed\u2010oil ILE containing fish oil (MOLE) at 3\u2009g\/kg\/day. These treatment groups were also compared with historic controls who received SOLE at 2\u20133\u2009g\/kg\/day (SOLE Historic). We defined IFALD as a direct bilirubin &gt;2\u2009mg\/dl on two measurements. Secondary outcomes included laboratory, growth, clinical, and nutrition outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24 prospective and 24 historic patients were included. There was no difference in the rate of IFALD. However, there was a difference in the weekly change of direct bilirubin levels (SOLE Historic +0.293\u2009mg\/dl\/week vs MOLE, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; SOLE Min +0.242\u2009mg\/dl\/week vs MOLE, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The MOLE group also had a lower direct bilirubin at study completion (SOLE Historic, 1.7\u2009\u00b1\u20091.7\u2009mg\/dl; SOLE Min, 1.6\u2009\u00b1\u20091.4\u2009mg\/dl; MOLE, 0.4\u2009\u00b1\u20090.4\u2009mg\/dl; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and received greater total calories (<jats:italic>P<\/jats:italic>\u2009=\u20090.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rate of IFALD did not differ when comparing ILE strategies in neonates requiring abdominal surgery. However, the MOLE group maintained significantly lower direct bilirubin levels over time while receiving increased calories. This pilot study highlights the need for further randomized controlled trials comparing these ILE strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2483","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T07:08:25Z","timestamp":1676099305000},"page":"482-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lipid strategies to prevent intestinal failure\u2013associated liver disease in neonates: A pilot trial"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8646-8402","authenticated-orcid":false,"given":"Katie A.","family":"Huff","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine, Department of Pediatircs, Division of Neonatal\u2010Perinatal Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Cruse","sequence":"additional","affiliation":[{"name":"Riley Hospital for Children at Indiana University Health, Department of Pharmacy and Clinical Nutrition Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Vanderpool","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicne, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,12]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/MPG.0000000000001722","article-title":"Intestinal rehabilitation programs in the management of pediatric intestinal failure and short bowel syndrome","volume":"65","author":"Merritt 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