{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:02:04Z","timestamp":1790308924798,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Iron deficiency and iron deficiency anemia are common in pediatric inflammatory bowel disease and often require supplementation with iron. There is a paucity of literature regarding optimal iron formulation. The aim of this study is to compare outcomes in pediatric patients with inflammatory bowel disease receiving either iron sucrose or ferric carboxymaltose during inpatient hospitalizations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center retrospective study of pediatric patients with inflammatory bowel disease admitted for newly diagnosed disease or flare who received either iron sucrose or ferric carboxymaltose. Linear regression was used to assess differences in iron repletion. Longitudinal linear mixed\u2010effects models and generalized estimating equations compared hematologic and iron outcomes 6 months post\u2013iron repletion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients received ferric carboxymaltose. Sixty\u2010nine patients received iron sucrose. Baseline hemoglobin and iron deficits were similar in both groups. A larger percentage of iron deficit was repleted in the ferric carboxymaltose group (81.4%) compared with iron sucrose (25.9%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with fewer infusions. Cumulative doses of ferric carboxymaltose administered (18.7\u2009mg\/kg) were higher than iron sucrose (6.1\u2009mg\/kg) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Hemoglobin increased more quickly with ferric carboxymaltose compared with iron sucrose (<jats:italic>P<\/jats:italic>\u2009=\u20090.04 and <jats:italic>P<\/jats:italic>\u2009=\u20090.02, respectively). Total iron binding capacity and red cell distribution width levels decreased more over time with ferric carboxymaltose vs iron sucrose (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01 and <jats:italic>P<\/jats:italic>\u2009=\u20090.01, respectively). No adverse effects were seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hematologic and iron parameters responded more quickly with fewer infusions in patients who received ferric carboxymaltose vs iron sucrose. Patients who received ferric carboxymaltose achieved a higher percentage of iron deficit repleted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2515","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T03:11:54Z","timestamp":1684379514000},"page":"670-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between iron deficit repletion with ferric carboxymaltose relative to iron sucrose in children with inflammatory bowel disease: A retrospective cohort study"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-0075","authenticated-orcid":false,"given":"Tanyaporn K.","family":"Kaenkumchorn","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Medical College of Wisconsin\u2010Children's Wisconsin Milwaukee Wisconsin USA"},{"name":"Department of Pediatrics Medical College of 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Medicine University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0575-6475","authenticated-orcid":false,"given":"Hengqi B.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Hepatology Seattle Children's Hospital Seattle Washington USA"},{"name":"Department of Pediatrics, School of Medicine University of Washington Seattle Washington 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