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The results of both trials support a \u201cless\u2010is\u2010more\u201d paradigm shift in the early acute phase of critical illness. In this review, the authors outline and appraise the results of the NUTRIREA\u20102 and NUTRIREA\u20103 trials, introduce the concept of identifying the \u201csweet spot\u201d for nutrition dose based on severity of illness\/nutrition risk and nutrition dose, and identify the unintended consequences of delivering full\u2010dose nutrition in sicker critically ill patients during the early acute phase of critical illness.<\/jats:p>","DOI":"10.1002\/jpen.2539","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T21:40:31Z","timestamp":1687642831000},"page":"859-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Nutrition dose in the early acute phase of critical illness: Finding the sweet spot and heeding the lessons from the NUTRIREA trials"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-7670","authenticated-orcid":false,"given":"Jayshil J.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7136-5408","authenticated-orcid":false,"given":"Todd W.","family":"Rice","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-3544","authenticated-orcid":false,"given":"Manpreet S.","family":"Mundi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-2039","authenticated-orcid":false,"given":"Christian","family":"Stoppe","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine University Hospital Wuerzberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"McClave","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine University of Louisville Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1793"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426503018004279"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.137"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502826"},{"issue":"5","key":"e_1_2_9_6_1","first-page":"499","article-title":"Energy\u2010dense versus routine enteral nutrition in the critically ill","volume":"380","author":"Peake SL","year":"2019","journal-title":"N Engl J Med"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.08.037"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32146-3"},{"key":"e_1_2_9_9_1","unstructured":"ReignierJ PlantefeveG MiraJP et al.NUTRIREA\u20103 Trial Investigators; 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