{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:05:44Z","timestamp":1780506344816,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Reported outcomes for parenteral nutrition (PN)\u2013related complications in older adult patients with acute intestinal failure who are receiving PN in the acute hospital setting are limited. Our study aims to compare PN\u2010related complications between older and younger adult patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective descriptive study of inpatients who were administered PN from January 1, 2019, to December 31, 2019, was performed. Patients were categorized into older (\u226565 years old) and younger (&lt;65 years old) adult groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred thirty\u2010five patients were included. There were 103 patients in the older adult group (mean age: 73.9 [SD: 6.9] years) and 132 patients in the younger adult group (mean age: 52.4 [SD: 12.5] years). There was a significantly higher Charlson Comorbidity Index score and lower Karnofsky score in the older adult group. The older adult group received significantly lower total energy (20.8 [SD: 7.8] vs 22.8 [SD: 6.3] kcal\/kg\/day), dextrose (3.1 [SD: 1.4] vs 3.6 [SD: 1.4] g\/kg\/day), and protein (1.1 [SD: 0.4] vs 1.2 [SD: 0.3] g\/kg\/day) than the younger group received. The mean length of stay was significantly shorter in the older adult group (35.9 [SD: 21.3] vs 59.8 [SD: 55.3]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There was no significant difference in PN\u2010related complications and clinical outcomes (catheter\u2010related bloodstream infections, hypoglycemia or hyperglycemia, fluid overload, or inpatient mortality) between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite more comorbidities in the older adult, the usage of PN in older adult patients with acute intestinal failure was associated with neither an increased rate of PN\u2010related complications nor worse clinical outcomes when compared with that of younger patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2578","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T10:55:01Z","timestamp":1700650501000},"page":"174-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Parenteral nutrition\u2010related complications in older patients with acute intestinal failure: A descriptive cohort study"],"prefix":"10.1002","volume":"48","author":[{"given":"Garrett","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Chang Chuen","family":"Cheah","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poh Bee","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Boo","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dietetics Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet Ngian Choo","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Ye","family":"Cheang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0247-8158","authenticated-orcid":false,"given":"Rachel Jia Ling","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaw Sim","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dietetics Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis Kim Chye","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-013X","authenticated-orcid":false,"given":"Ennaliza","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11148"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-018-0308-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP60352"},{"key":"e_1_2_8_5_1","unstructured":"Department of Statistics Singapore. 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