{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:49:07Z","timestamp":1782992947853,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Achievement of enteral autonomy (EA) is the ultimate treatment goal in pediatric intestinal failure (IF). We aimed to assess predictors of EA in pediatric short bowel syndrome (SBS) and explore the impact of residual small bowel (SB) and large bowel (LB) length on EA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was performed on infants aged &lt;12 months (<jats:italic>n<\/jats:italic>\u2009=\u2009367, six centers) with SBS referred between 2010 and 2015. The cohort was stratified based on the achievement of EA. Statistical testing was completed using <jats:italic>t\u2010test<\/jats:italic>, chi\u2010square, Cox proportional hazards regression model, and Kaplan\u2010Meier analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EA was achieved in 229 patients. In the multivariable analysis, the percentage of residual LB (hazard ratio [HR]\u2009=\u20091.02; 95% CI\u2009=\u20091.01\u20131.02) and SB (HR\u2009=\u20091.01; 95% CI\u2009=\u20091.01\u20131.02) length, presence of the ileocecal valve (HR\u2009=\u20092.02; 95% CI=1.41\u20132.88), and not coming from a high\u2010volume transplantation center (HR\u2009=\u20092.42; 95% CI\u2009=\u20091.68\u20133.49) were positively associated with EA, whereas a negative association was seen with the presence of stoma at the time when shortest remnant was documented (HR\u2009=\u20090.72; 95% CI\u2009=\u20090.52\u20131.00). EA achievement was significantly different between the anatomical subgroups (log\u2010rank test <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with an EA rate of 80.4% in infants with \u226550% SB and LB (median time 209 days); 62.5% with \u226550% SB and &lt;50% LB (397 days); 58.3% with &lt;50% SB and \u226550% LB (1192 days), and 25.9% with &lt;50% SB and LB. Necrotizing enterocolitis (NEC) was not associated with a better achievement of EA (NEC vs other etiologies: log\u2010rank test <jats:italic>P<\/jats:italic>\u2009=\u20090.33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, 62% of infants with IF secondary to SBS achieved EA over a mean time of follow\u2010up of 2.3 years. A colon length of &gt;50% can compensate for the loss of small bowel (&lt;50%) and account for similar EA rates as those in children with residual SB\u2009&gt;\u200950%.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2587","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T01:55:00Z","timestamp":1702000500000},"page":"231-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Small and large bowel anatomy is associated with enteral autonomy in infants with short bowel syndrome: A retrospective cohort study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-8984","authenticated-orcid":false,"given":"Natascha S.","family":"Sandy","sequence":"first","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), Hospital for Sick Children University of Toronto Toronto Ontario Canada"},{"name":"Department of Pediatrics University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-7385","authenticated-orcid":false,"given":"Amin J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Starship Child Health University of Auckland Auckland New Zealand"},{"name":"National Intestinal Failure &amp; Rehabilitation Service (NIFRS) Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-735X","authenticated-orcid":false,"given":"Paul W.","family":"Wales","sequence":"additional","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), Hospital for Sick Children University of Toronto Toronto Ontario Canada"},{"name":"Cincinnati Center of Excellence in Intestinal Rehabilitation (CinCEIR), Cincinnati Children's Hospital Medical Center University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo K.","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-295X","authenticated-orcid":false,"given":"Christina","family":"Belza","sequence":"additional","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harween","family":"Dogra","sequence":"additional","affiliation":[{"name":"Paediatric Liver, GI &amp; Nutrition Centre King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Starship Child Health University of Auckland Auckland New Zealand"},{"name":"National Intestinal Failure &amp; Rehabilitation Service (NIFRS) Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Gattini","sequence":"additional","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hind","sequence":"additional","affiliation":[{"name":"Cincinnati Center of Excellence in Intestinal Rehabilitation (CinCEIR), Cincinnati Children's Hospital Medical Center University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1557-1773","authenticated-orcid":false,"given":"David","family":"Mercer","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M.","family":"Povondra","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoric","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition, Nutrition Support and Intestinal Failure team Birmingham Women's and Children's Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Avitzur","sequence":"additional","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), Hospital for Sick Children University of Toronto Toronto Ontario Canada"},{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition, Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001722"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.036"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb12159.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1072250"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.109405"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz110"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.03.062"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002602"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.10.023"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.02.030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.4332"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.10.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.03.040"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000179647.24046.03"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181a118ef"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.02.028"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)80058-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17150"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.06.025"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.031"},{"key":"e_1_2_9_23_1","unstructured":"RaghuVLH SamoylovaM ParkC SudanD AvitzurY. Predictors of early enteral autonomy in an international cohort of children with intestinal failure\u2014Results from the Intestinal Failure Registry.Abstract presented at International Pediatric Intestinal Failure and Rehabilitation Symposium (PIFRS) 2022."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1691"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114481"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70489-5"},{"issue":"3","key":"e_1_2_9_27_1","first-page":"310","article-title":"Construction of an ileocecal valve and its role in massive resection of the small intestine","volume":"152","author":"Ricotta J","year":"1981","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113520005"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.2587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:41:53Z","timestamp":1760866913000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.2587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jpen.2587"],"URL":"https:\/\/doi.org\/10.1002\/jpen.2587","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"2023-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}