{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T21:10:13Z","timestamp":1767474613569,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Using soybean oil\u2013based lipid emulsions (Intralipid), which contain higher amounts of \u03c9\u20106 fatty acids and phytosterols in parenteral nutrition, is a risk factor for cholestasis (parenteral nutrition\u2013associated cholestasis [PNAC]). An alternative form of a mixed lipid emulsion (SMOFlipid) has been developed to reduce the risk of PNAC, but significant benefits over Intralipid in very low birth weight (VLBW) infants have yet to be demonstrated. The aim of this study was to compare the differences in PNAC incidence in VLBW infants receiving SMOFlipid vs Intralipid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted in Sir Run Run Shaw Hospital of the Zhejiang University School of Medicine, Hangzhou, China, from January 2016 to March 2022. In total, 235 VLBW infants were administered SMOFlipid or Intralipid for \u226521 days and were included in the study. The primary outcome was the incidence of PNAC. Secondary outcomes included bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, late\u2010onset sepsis, length of stay, weight 28 days after birth, severity of PNAC, and the time to reversal of PNAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four VLBW infants (35.5%) in the SMOFlipid group vs 41 (36.9%) in the Intralipid group achieved PNAC (<jats:italic>P<\/jats:italic>\u2009=\u20090.817). The subgroup analysis showed that the peak direct bilirubin level was lower (median [interquartile range] 55.6 [36.4] vs 118.4 [77.2] \u03bcmol\/L; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and the time to reversal of PNAC was shorter (44 [49] vs 96 [61]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in the SMOFlipid group than in the Intralipid group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SMOFlipid may represent a better alternative for VLBW infants who require prolonged parenteral nutrition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2588","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T01:55:38Z","timestamp":1702000538000},"page":"345-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between two different lipid injectable emulsions and parenteral nutrition\u2013associated cholestasis in very low birth weight infants: A retrospective cohort study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2251-1982","authenticated-orcid":false,"given":"Xing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Qiantang Campus, Sir Run Run Shaw Hospital, College of Medicine, Hangzhou Qiantang Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Feng","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hangzhou Medical College Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Qiantang Campus, Sir Run Run Shaw Hospital, College of Medicine, Hangzhou Qiantang Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao\u2010Fa","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Qiantang Campus, Sir Run Run Shaw Hospital, College of Medicine, Hangzhou Qiantang Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care Unit, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care Unit, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care Unit, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1843"},{"key":"e_1_2_8_3_1","unstructured":"Intralipid 20% (a 20% IV fat emulsion). Package insert. Freseneius Kabi;2022. Accessed May 2022.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/020248s026lbl.pdf"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1002\/jpen.1756","article-title":"Lipids in parenteral nutrition: biological aspects","volume":"44","author":"Calder PC","year":"2020","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-319108"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607108319802"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006898"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030895"},{"key":"e_1_2_8_9_1","unstructured":"SMOFlipid.Prescribing Information. Fresenius Kabi; 2022. 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