{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:08:41Z","timestamp":1780492121939,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Catheter\u2010related bloodstream infections (CRBSIs) in patients receiving home parenteral nutrition (HPN) for chronic intestinal failure (CIF) are associated with significant morbidity and financial costs. Taurolidine is associated with a reduction in bloodstream infections, with limited information on the cost\u2010effectiveness as the primary prevention. This study aimed to determine the cost\u2010effectiveness of using taurolidine\u2010citrate for the primary prevention of CRBSIs within a quaternary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with CIF receiving HPN were identified between January 2015 and November 2022. Data were retrospectively collected regarding patient demographics, HPN use, CRBSI diagnosis, and use of taurolidine\u2010citrate. The direct costs associated with CRBSI\u2010associated admissions and taurolidine\u2010citrate use were obtained from the coding department using a bottom\u2010up approach. An incremental cost\u2010effective analysis was performed, with a time horizon of 4 years, to compare the costs associated with primary and secondary prevention against the outcome of cost per infection avoided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four patients received HPN within this period. The CRBSI rates were 3.25 infections per 1000 catheter days before the use of taurolidine\u2010citrate and 0.35 infections per 1000 catheter days after taurolidine\u2010citrate use. The incremental cost\u2010effectiveness ratio indicates primary prevention is the weakly dominant intervention, with the base case value of $27.04 per CRBSI avoided. This held with one\u2010way sensitivity analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taurolidine\u2010citrate in the primary prevention of CRBSIs in patients with CIF receiving HPN is associated with reduced hospital costs and infection rates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2589","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T01:55:24Z","timestamp":1702000524000},"page":"165-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cost\u2010effectiveness of taurolidine\u2010citrate in a cohort of patients with intestinal failure receiving home parenteral nutrition"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5506-8008","authenticated-orcid":false,"given":"Thomas J.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Princess 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