{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:00:17Z","timestamp":1780074017792,"version":"3.54.0"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T00:00:00Z","timestamp":1705104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Opioid\u2010induced constipation (OIC) is a well\u2010known phenomenon, although there is limited literature evaluating the incidence of OIC in children admitted to the pediatric intensive care unit (PICU). The primary aim of this study was to determine the incidence of OIC in the PICU and to determine if it is associated with a higher rate of morbidities or prolonged length of stay (LOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010center retrospective chart review from July 1, 2014, to June 30, 2015, in our PICU. We included all patients aged \u226418 years with a PICU stay of \u226596\u2009h who received opioids during their admission. Data were collected on the frequency of bowel movements and characteristics of opioid administration. Demographic and clinical data were obtained from Virtual Pediatric Systems, LLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 94 patients who met the study criteria, 39.4% developed constipation. These patients tended to be older (<jats:italic>P<\/jats:italic>\u2009=\u20090.06) and were noted to weigh more (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). There was no significant difference in the total or median daily doses, duration of opioid treatment, or mode of administration. Constipation rates did not differ by the severity of illness. There was a higher incidence of constipation in the patients who were admitted for neurological issues or after trauma or abdominal surgery (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). Patients with constipation had a longer LOS than patients without constipation, but the difference was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that opioid use is not the sole risk factor for constipation in the PICU setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2592","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T02:29:40Z","timestamp":1703384980000},"page":"354-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of opioid\u2010induced constipation in the pediatric intensive care unit: A descriptive cohort study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6175-6484","authenticated-orcid":false,"given":"Meghan D.","family":"Roller","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Critical Care Medical College of Wisconsin Milwaukee Wisconsin USA"},{"name":"Children's Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4623-1237","authenticated-orcid":false,"given":"Apurva","family":"Panchal","sequence":"additional","affiliation":[{"name":"Critical Care Children's Mercy Hospital and Clinics Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Duesing","sequence":"additional","affiliation":[{"name":"Children's Wisconsin Milwaukee Wisconsin USA"},{"name":"Department of General Surgery Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-9739","authenticated-orcid":false,"given":"Theresa A.","family":"Mikhailov","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Critical Care Medical College of Wisconsin Milwaukee Wisconsin USA"},{"name":"Children's Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0753-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12417"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.016"},{"issue":"8","key":"e_1_2_8_6_1","first-page":"1347","article-title":"Management of common opioid\u2010induced adverse effects","volume":"74","author":"Swegle JM","year":"2006","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315627801"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg275"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20130018"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2009.03.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.06.046"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","unstructured":"DrossmanDA. Functional gastrointestinal disorders: history pathophysiology clinical features and Rome IV.Gastroenterology. Published online February 19 2016.doi:10.1053\/j.gastro.2016.02.032","DOI":"10.1053\/j.gastro.2016.02.032"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.2592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:59:44Z","timestamp":1760878784000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.2592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,13]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/jpen.2592"],"URL":"https:\/\/doi.org\/10.1002\/jpen.2592","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,13]]},"assertion":[{"value":"2023-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}