{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:17:35Z","timestamp":1787167055647,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The microbiome has a pivotal role in intestinal health, and nutrition has a major role shaping its structure. Enteral deprivation, in which no oral\/enteral nutrition is administered, is common in hospitalized\/gastrointestinal patients. The dynamics that enteral deprivation exerts on the microbial community, specifically in the small intestine, are not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Enteral deprivation was modeled with exclusive parenteral nutrition (EPN) mice. Mice were allocated to receive either EPN or saline and chow (control) and euthanized after 0, 2, 4, or 6 days. DNA was extracted from jejunum, ileum, and colon content. 16S sequencing was used to compare changes in microbial communities between groups. Functional pathways were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EPN\u2010treated mice showed community changes throughout the intestine. Beta diversity in colon showed clear separation between the groups (Bray\u2010Curtis,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Time\u2010dependent dynamics were seen in ileal but not jejunal samples. Alpha diversity was lower in the colon of EPN mice compared with control\/baseline mice (Chao1,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) but not in ileum\/jejunum. Progressive loss of single\u2010taxon domination was seen, most notably in the small intestine. This was accompanied by increases\/decreases in specific taxa. A clear separation was seen in the functional capacity of the community between fed and enterally deprived mice at the ileum and colon, which was observed early on.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Enteral deprivation disturbs the microbial community in a spatial and dynamic manner. There should be further focus on studying the effect of these changes on the host.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.2624","type":"journal-article","created":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T10:44:36Z","timestamp":1711277076000},"page":"502-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Microbiome changes under enteral deprivation are dynamic and dependent on intestinal location"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-4930","authenticated-orcid":false,"given":"Haggai","family":"Bar\u2010Yoseph","sequence":"first","affiliation":[{"name":"Gastroenterology Department Rambam Health Care Campus Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion \u2010 Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1016-3765","authenticated-orcid":false,"given":"Avril","family":"Metcalfe\u2010Roach","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia Vancouver British Columbia Canada"},{"name":"Department of Microbiology and Immunology University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Cirstea","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia Vancouver British Columbia Canada"},{"name":"Department of Microbiology and Immunology University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Brett","family":"Finlay","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia Vancouver British Columbia Canada"},{"name":"Department of Microbiology and Immunology University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615609904"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2013.00105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00321.2016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0332-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607106030006474"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","unstructured":"WickhamH.ggplot2: Elegant Graphics for Data Analysis. Springer; 2009.","DOI":"10.1007\/978-0-387-98141-3"},{"key":"e_1_2_8_11_1","unstructured":"OksanenJ KindtR LegendreP et al.Vegan: Community Ecological Package.R;2007."},{"key":"e_1_2_8_12_1","unstructured":"LahtiSS ShettyS.Tools for Microbiome Analysis in R. R;2017."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v26.27663"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-2-15"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009442"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1103"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201746"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.162388"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.5.1117"},{"issue":"6","key":"e_1_2_8_22_1","first-page":"350","article-title":"Gut\u2010origin sepsis: evolution of a concept","volume":"10","author":"Deitch EA","year":"2012","journal-title":"Surg"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00088.2016"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102662"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05989-7"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619852255"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2019.07.006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05723-9"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806573115"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28034-z"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.10.002"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2010.02294.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.05.005"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2023.12.020"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00744-8"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.2624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:44:44Z","timestamp":1760877884000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.2624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,24]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/jpen.2624"],"URL":"https:\/\/doi.org\/10.1002\/jpen.2624","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,24]]},"assertion":[{"value":"2023-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}