{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:30:14Z","timestamp":1770496214472,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enteral nutrition (EN) is one method of nutrition support for children and adolescents receiving extracorporeal membrane oxygenation (ECMO) therapy, and there are no guidelines for its use in this population. We conducted a systematic review to determine whether EN is effective and safe in children supported by ECMO. We searched the Cochrane Library database, MEDLINE, and Embase on Ovid in March 2023 to identify studies that evaluated children and adolescents who received ECMO and were treated with EN. Random effects meta\u2010analysis was used to estimate the odds of mortality with EN compared with parenteral nutrition (PN). A total of 14 studies were included in this review with 1650 patients (796 received EN). The median duration of ECMO was 5\u201310 days, and the median EN initiation time ranged from 23\u2009h to 7 days. The pooled results suggest no significant difference in mortality with EN compared with PN (odds ratio [OR]\u2009=\u20090.77; 95% CI, 0.56\u20131.05; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200926%). Exclusion of the only study that reported an increase in mortality resulted in a borderline significant reduction in mortality with EN (OR\u2009=\u20090.71; 95% CI, 0.51\u20131.00; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200926%). The predictors of EN were male sex, older age, heavier weight, greater height, cardiac diagnosis, longer duration of ECMO, and use of venovenous ECMO. Most studies suggest no correlation between EN and complications. EN use in children and adolescents who receive ECMO does not appear to be associated with increased mortality compared with PN and was safe in terms of intestinal complications and feeding intolerance.<\/jats:p>","DOI":"10.1002\/jpen.2626","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T10:18:16Z","timestamp":1711793896000},"page":"406-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enteral nutrition in children and adolescents who receive extracorporeal membrane oxygenation and its impact on complications and mortality: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"48","author":[{"given":"Xiuhong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Post\u2010Qualifying Healthcare Practice Birmingham City University Birmingham UK"},{"name":"Shenzhen Children's Hospital, Cardiothoracic Surgery Department Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Fan","sequence":"additional","affiliation":[{"name":"Shenzhen Children's Hospital, Cardiothoracic Surgery Department Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Pan","sequence":"additional","affiliation":[{"name":"Shenzhen Children's Hospital, Cardiothoracic Surgery Department Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-1586","authenticated-orcid":false,"given":"Chun Shing","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Post\u2010Qualifying Healthcare Practice Birmingham City University Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197203232861204"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2017.06.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.09.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001709"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-018-4225-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2020.03.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10212"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.666464"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117711387"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/pm-21-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003496"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003317"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1032"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"e_1_2_8_16_1","unstructured":"WellsGA SheaB O'ConnellD et al. 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