{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:53:12Z","timestamp":1792173192754,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Survival from pediatric critical illness in high\u2010income countries is high, and the focus now must be on optimizing the recovery of survivors. Muscle mass wasting during critical illness is problematic, so identifying factors that may reduce this is important. Therefore, the aim of this study was to examine the relationship between quadricep muscle mass wasting (assessed by ultrasound), with protein and energy intake during and after pediatric critical illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study in a mixed cardiac and general pediatric intensive care unit in England, United Kingdom. Serial ultrasound measurements were undertaken at day 1, 3, 5, 7, and 10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four children (median age 6.65 [0.47\u201357.5] months) were included, and all showed a reduction in quadricep muscle thickness during critical care admission, with a mean muscle wasting of 7.75%. The 11 children followed\u2010up had all recovered their baseline muscle thickness by 3 months after intensive care discharge. This muscle mass wasting was not related to protein (<jats:italic>P<\/jats:italic>\u2009=\u20090.53, <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.019) (95% CI: \u22120.011 to 0.049) or energy intake (<jats:italic>P<\/jats:italic>\u2009=\u20090.138, <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.375 95% CI: \u22120.144 to 0.732) by 72\u2009h after admission, nor with severity of illness, highest C\u2010reactive protein, or exposure to intravenous steroids. Children exposed to neuromuscular blocking drugs exhibited 7.2% (95% CI: \u22120.13% to 14.54%) worse muscle mass wasting, but this was not statistically significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.063).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study did not find any association between protein or energy intake at 72\u2009h and quadricep muscle mass wasting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2627","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T10:24:32Z","timestamp":1711794272000},"page":"615-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between protein intake and muscle wasting in critically ill children: A prospective cohort study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-8209","authenticated-orcid":false,"given":"Lyvonne N.","family":"Tume","sequence":"first","affiliation":[{"name":"Faculty of Health, Special Care &amp; Medicine Edge Hill University Ormskirk UK"},{"name":"Pediatric Intensive Care Unit Alder Hey Children's NHS Foundation Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Simons","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Alder Hey Children's NHS Foundation Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1620-0114","authenticated-orcid":false,"given":"Lynne","family":"Latten","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Alder Hey Children's NHS Foundation Trust Liverpool UK"},{"name":"Alder Hey Children's NHS Foundation Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-7218","authenticated-orcid":false,"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Applied Health Research and Hull York Medical School University of Hull Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-8626","authenticated-orcid":false,"given":"Paul","family":"Comfort","sequence":"additional","affiliation":[{"name":"Directorate of Psychology and Sport University of Salford Salford Greater Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Compton","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Alder Hey Children's NHS Foundation Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Wagh","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Alder Hey Children's NHS Foundation Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archie","family":"Veale","sequence":"additional","affiliation":[{"name":"Patient and Public Engagement Expert Carlisle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-1104","authenticated-orcid":false,"given":"Frederic V.","family":"Valla","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,30]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Paediatric Intensive Care Audit Network (PICANet) Annual Report 2016\u20102018. 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