{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:18:28Z","timestamp":1791497908266,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Feeding difficulty is widely recognized in patients with Down syndrome, and many patients require gastrostomy tube (G\u2010tube) placement for nutrition. No reliable factors have been identified to predict the expected duration of G\u2010tube feeds in patients with Down syndrome. This descriptive cohort study aimed to determine the factors affecting the duration of G\u2010tube feeds. We also investigated change in body mass index (BMI) from G\u2010tube placement to discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of patients with Down syndrome seen by a pediatric gastroenterologist at a tertiary care center between September 1986 and December 2021 were reviewed. Data collection included demographics, anthropometrics, comorbidities, and feeding route. Comparison was performed between patients who discontinued G\u2010tube feeds and those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred twenty patients (45% female) were included. The median age at G\u2010tube placement was 5 months (interquartile range [IQR]: 0.2\u20131.3 years). There were 113 (51%) patients who discontinued G\u2010tube feeds, after a median duration of 31.6 months (IQR: 15.6\u201355.7 months). Tracheostomy was the only covariant associated with a longer duration of G\u2010tube feeds (158 months vs 53 months; <jats:italic>P<\/jats:italic>\u2009=\u20090.002). Neither age at G\u2010tube placement nor any comorbidities were associated with BMI status at discontinuation of G\u2010tube.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our cohort of patients with Down syndrome, age at placement of G\u2010tube did not impact the duration of G\u2010tube feeds. Most patients who had a G\u2010tube placed were likely to require enteral feeds for at least 1 year. Those who had a tracheostomy needed their G\u2010tube for a longer time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2637","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T02:48:56Z","timestamp":1715136536000},"page":"605-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Factors influencing gastrostomy tube feeding duration and nutrition outcomes in pediatric patients with Down syndrome: A descriptive cohort study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7574-2043","authenticated-orcid":false,"given":"Thomas","family":"Aviles","sequence":"first","affiliation":[{"name":"Department of Pediatrics Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Giangiordano","sequence":"additional","affiliation":[{"name":"Department of Nutrition Therapy Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Evelyn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Dorfman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kaul","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology 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