{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:14:18Z","timestamp":1788804858940,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with inflammatory bowel disease (IBD) are at increased risk of thrombosis. They often need parenteral nutrition (PN) requiring intravenous access for prolonged periods. We assessed the risk of deep vein thrombosis (DVT) associated with peripherally inserted central catheters (PICCs) and tunneled catheters for patients with IBD receiving home PN (HPN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Cleveland Clinic HPN Registry, we retrospectively studied a cohort of adults with IBD who received HPN between June 30, 2019 and January 1, 2023. We collected demographics, catheter type, and catheter\u2010associated DVT (CADVT) data. We performed descriptive statistics and Poisson tests to compare CADVT rates among parameters of interest. We generated Kaplan\u2010Meier graphs to illustrate longevity of CADVT\u2010free survival and a Cox proportional hazard model to calculate the hazard ratio associated with CADVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We collected data on 407 patients, of which, 276 (68%) received tunneled catheters and 131 (32%) received PICCs as their initial catheter. There were 17 CADVTs with an overall rate of 0.08 per 1000 catheter days, whereas individual rates of DVT for PICCs and tunneled catheters were 0.16 and 0.05 per 1000 catheter days, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). After adjusting for age, sex, and comorbidity, CADVT risk was significantly higher for PICCs compared with tunneled catheters, with an adjusted hazard ratio of 2.962 (95% CI=1.140\u20137.698; <jats:italic>P<\/jats:italic>\u2009=\u20090.025) and adjusted incidence rate ratio of 3.66 (95% CI=2.637\u20134.696; <jats:italic>P<\/jats:italic>\u2009=\u20090.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that CADVT risk is nearly three times higher with PICCs compared with tunneled catheters. We recommend tunneled catheter placement for patients with IBD who require HPN infusion greater than 30 days.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2647","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T11:26:05Z","timestamp":1719833165000},"page":"562-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between tunneled catheter placement and catheter\u2010associated deep venous thrombosis in adults with inflammatory bowel disease receiving home parenteral nutrition: A retrospective cohort study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0778-2319","authenticated-orcid":false,"given":"Mohamed Tausif","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition, Center for Human Nutrition, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L.","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition, Center for Human Nutrition, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Koenen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology University of Arkansas for Medical Sciences Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Al\u2010Yaman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Joseph Mercy Health System Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Bestgen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition, Center for Human Nutrition, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Regueiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition, Center for Human Nutrition, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald F.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition, Center for Human Nutrition, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2002697"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.12.027"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043372"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"32","article-title":"Increased lifetime risk of intestinal complications and extraintestinal manifestations in Crohn's disease and ulcerative colitis","volume":"18","author":"Lichtenstein GR","year":"2022","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i16.2445"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000458144"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2051"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2570"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.04.013"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03547.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.065"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9060562"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615594011"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i36.5732"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001162"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122865"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.06.009"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.03.015"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617734528"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115586575"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2203001181"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01398.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i12.3173"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000274"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12294"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-015-0052-2"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.481065"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.103"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607105029004272"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10180"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010172"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2078"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02596321"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114521833"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1455"},{"issue":"1","key":"e_1_2_11_37_1","first-page":"39","article-title":"Improving outcomes with parenteral nutrition","volume":"8","author":"Kirby DF","year":"2012","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113511992"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10474"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-015-0044-2"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.04.024"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284819827692"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X13477715"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061388"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.18936"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607116655449"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2020.03.025"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.01.020"},{"issue":"1","key":"e_1_2_11_49_1","first-page":"256","article-title":"[Catheter occlusion and venous thrombosis prevention and incidence in adult home parenteral nutrition (HPN) programme patients]","volume":"27","author":"Puiggr\u00f2s C","year":"2012","journal-title":"Nutr Hosp"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000257"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2000.0103"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2323"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.12264"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.03.005"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13794"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.2647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:48:47Z","timestamp":1760863727000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.2647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/jpen.2647"],"URL":"https:\/\/doi.org\/10.1002\/jpen.2647","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}