{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:33:33Z","timestamp":1784640813541,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited evidence on benefits of SMOF lipids (mixed fatty acid emulsion of 30% soybean oil, 30% medium chain triglycerides, 25% olive oil, and 15% fish oil) in reducing parenteral nutrition\u2013associated cholestasis in extremely low birth weight infants, compared with soybean oil\u2013based Intralipid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare incidence of parenteral nutrition\u2013associated cholestasis in preterm infants who received Intralipid vs SMOF lipid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study on infants with birth weight &lt;1000\u2009g, admitted between January 2013 to December 2022, who received parenteral nutrition for &gt;14 days and divided them into two groups based on lipid emulsion received (Intralipid, <jats:italic>n<\/jats:italic>\u2009=\u2009187, SMOF, <jats:italic>n<\/jats:italic>\u2009=\u2009127). Primary outcome was incidence of parenteral nutrition\u2013associated cholestasis, defined as direct bilirubin \u22652\u2009mg\/dl.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics did not differ between the two groups. No significant difference was noted in parenteral nutrition\u2013associated cholestasis between the two groups on logistic regression, (adjusted odds ratio: 0.71, 95% confidence interval 0.35\u20131.42, <jats:italic>P<\/jats:italic> value 0.33) after adjusting for gestational age, parenteral nutrition days, lipid days, and late\u2010onset sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no difference in the rates of parenteral nutrition\u2013associated cholestasis between preterm infants administered SMOF lipids and those given Intralipid.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2689","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T05:49:07Z","timestamp":1726897747000},"page":"949-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between SMOF lipid and parenteral nutrition\u2013associated cholestasis compared with Intralipid in extremely low birth weight infants: A retrospective cohort study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4806-1657","authenticated-orcid":false,"given":"Pradeep Kumar","family":"Velumula","sequence":"first","affiliation":[{"name":"Mercy One Waterloo Medical Center Waterloo 50702 Iowa USA"},{"name":"Detroit Medical Center Hutzel Women's Hospital Detroit 48201 Michigan USA"},{"name":"Children's Hospital of Michigan Detroit 48201 Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1777-593X","authenticated-orcid":false,"given":"Praveen Kumar","family":"Boddu","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Hutzel Women's Hospital Detroit 48201 Michigan USA"},{"name":"Children's Hospital of Michigan Detroit 48201 Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Lulic\u2010Botica","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Hutzel Women's Hospital Detroit 48201 Michigan USA"},{"name":"Wayne State University Detroit 48201 Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Khanal","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Hutzel Women's Hospital Detroit 48201 Michigan USA"},{"name":"Children's Hospital of Michigan Detroit 48201 Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Amoah","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Hutzel Women's Hospital Detroit 48201 Michigan USA"},{"name":"Children's Hospital of Michigan Detroit 48201 Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Hutzel Women's Hospital Detroit 48201 Michigan USA"},{"name":"Children's Hospital of Michigan Detroit 48201 Michigan USA"},{"name":"Central Michigan University Mount Pleasant 48859 Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0796"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001334"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.11.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00396-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614555235"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181256492"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199902000-00008"},{"key":"e_1_2_8_9_1","unstructured":"US Food and Drug Administration. 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