{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:17:29Z","timestamp":1783037849159,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate and propose novel approaches to calculate muscle quality index (MQI) using muscle mass derived from single\u2010frequency bioelectrical impedance analysis (SF\u2010BIA) and calf circumference in both unadjusted and body mass index (BMI)\u2013adjusted forms. In addition, we examined their prognostic significance in patients with cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A secondary analysis was conducted on a prospective cohort study of patients with cancer. Handgrip strength was measured. SF\u2010BIA was conducted to estimate appendicular lean soft tissue (ALST, in kilograms). MQI was calculated using three approaches: (1) the ratio of handgrip strength to ALST (MQI<jats:sub>SF\u2010BIA<\/jats:sub>), (2) the ratio of handgrip strength to calf circumference (MQI<jats:sub>calf\u2009circumference<\/jats:sub>), and (3) the ratio of handgrip strength to BMI\u2010adjusted calf circumference (MQI<jats:sub>adj.\u2009calf\u2009circumference<\/jats:sub>). Maximally selected log\u2010rank was calculated to estimate their cutoff values to predict survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred eighty\u2010four patients were included (51.1% men; median age, 61 years). Solid tumors were the most frequent (89.8%). All approaches to MQI (MQI<jats:sub>SF\u2010BIA<\/jats:sub>, MQI<jats:sub>calf\u2009circumference<\/jats:sub>, and MQI<jats:sub>adj.\u2009calf\u2009circumference<\/jats:sub>) were independent predictors of 6\u2010month mortality. The found cutoffs were (1) MQI<jats:sub>SF\u2010BIA<\/jats:sub> (&lt;1.52 for men, &lt;0.63 for women), (2) MQI<jats:sub>calf\u2009circumference<\/jats:sub> (&lt;0.74 for men, &lt;0.24 for women), and (3) MQI<jats:sub>adj.\u2009calf\u2009circumference<\/jats:sub> (&lt;0.75 for men, &lt;0.25 for women).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study introduces MQI<jats:sub>SF\u2010BIA,<\/jats:sub> MQI<jats:sub>calf\u2009circumference<\/jats:sub>, and MQI<jats:sub>adj.\u2009calf\u2009circumference<\/jats:sub> as future potential surrogate methods for computing MQI in clinical practice when other robust procedures are unavailable, pending further validation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2701","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:18:57Z","timestamp":1730870337000},"page":"112-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic significance of novel muscle quality index utilization in hospitalized adults with cancer: A secondary analysis"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5412-6467","authenticated-orcid":false,"given":"Jarson P.","family":"da Costa Pereira","sequence":"first","affiliation":[{"name":"Department of Nutrition, Postgraduate Program in Nutrition Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-5641","authenticated-orcid":false,"given":"Carla M.","family":"Prado","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Nutritional Science, Human Nutrition Research Unit University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3901-8182","authenticated-orcid":false,"given":"M. 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