{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T19:45:05Z","timestamp":1776887105385,"version":"3.51.2"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The goal of intestinal rehabilitation in children is to wean from parenteral nutrition (PN). The aim of this study was to identify factors associated with accelerated weaning and to evaluate long\u2010term outcomes of children receiving long\u2010term PN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of children managed by the Intestinal Rehabilitation Center at Cincinnati Children's Hospital. Medical history data were retrieved. The outcomes of children receiving long\u2010term chronic PN (&gt;2 years) were compared with those of children receiving short\u2010term chronic PN regimen (&lt;2 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort consisted of 112 children (58% boys, median [IQR] age of 6.0 [3.7\u20139.5] years). The group treated with a long\u2010term PN regimen had significantly shorter residual small bowel and large bowel compared with the group treated with a short\u2010term PN regimen (20% vs 60% and 75% vs 100%, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The lapse of time between PN and enteral feed initiation was longer in the group undergoing long\u2010term PN regimen than in the short\u2010term group (71 vs 32.5 days; <jats:italic>P<\/jats:italic>\u2009=\u20090.012). More episodes of central line\u2013associated bloodstream infection (CLABSI) and a higher percentage of feeding aversion was demonstrated in the long\u2010term PN group (2 [1\u20133] vs 1 [0\u20132] episodes and 36% vs 0%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Small bowel, colon length, enteral feed initiation, and frequency of CLABSI are factors associated with duration of PN regimen. A long\u2010term chronic PN regimen is associated with a higher risk of food aversion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2711","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T01:10:26Z","timestamp":1734484226000},"page":"207-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors associated with accelerated parenteral weaning in children with intestinal failure: A descriptive cohort study"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5177-9478","authenticated-orcid":false,"given":"Hadar","family":"Moran\u2010Lev","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center University of Cincinnati School of Medicine Cincinnati Ohio USA"},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Dana Dwek 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