{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:19:02Z","timestamp":1769919542494,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evidence indicates that, in pediatric patients with parenteral nutrition\u2013associated cholestasis (PNAC), the use of a 100% fish oil lipid emulsion (FOLE) increased the likelihood of PNAC resolution and reduced the likelihood of liver transplantation compared with a 100% soybean oil lipid emulsion (SOLE). To evaluate the potential economic benefit, we conducted a cost\u2010effectiveness analysis comparing FOLE with SOLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A discrete event simulation model evaluated cost\u2010effectiveness by simulating clinical outcomes and estimating associated healthcare costs in pediatric patients with PNAC receiving parenteral nutrition (PN) with FOLE (1\u2009g\/kg) or SOLE (1.9\u2009g\/kg) over a time horizon of 6 years. Model inputs for clinical outcomes were derived from the integrated analysis of two US Phase 3 trials (NCT00910104 and NCT00738101). Cost estimates were estimated from the perspective of the US payer including the cost of PN, transplantation, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total cost associated with FOLE was $69,847 USD vs $141,605 USD for SOLE. The cost reduction of $71,757 USD was attributable to the avoidance of liver transplantation (\u221215.7%) and reduction in adverse events (\u22124.8%). Life\u2010years and the quality\u2010adjusted life\u2010years were increased with FOLE compared with SOLE (by 0.248 and 0.295, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>By reducing the need for liver transplant and providing time to transition to full enteral nutrition, FOLE leads to cost\u2010savings, compared with SOLE, in pediatric patients with PNAC in the perspective of the US payer. These findings support the use of FOLE in pediatric patients with PNAC who require PN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2713","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T06:43:49Z","timestamp":1734763429000},"page":"180-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fish oil lipid emulsion compared with soybean oil lipid emulsion in pediatric patients with parenteral nutrition\u2010associated cholestasis: A cost\u2010effectiveness study"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0666-066X","authenticated-orcid":false,"given":"Massimiliano","family":"Povero","sequence":"first","affiliation":[{"name":"AdRes\u2010Health Economics and Outcome Research Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0431-896X","authenticated-orcid":false,"given":"Kathleen M.","family":"Gura","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, the Division of Gastroenterology, Hepatology, and Nutrition Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-9354","authenticated-orcid":false,"given":"Muralidhar H.","family":"Premkumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology Baylor College of Medicine, Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-8917","authenticated-orcid":false,"given":"Lorenzo","family":"Pradelli","sequence":"additional","affiliation":[{"name":"AdRes\u2010Health Economics and Outcome Research Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-2926","authenticated-orcid":false,"given":"Mark","family":"Puder","sequence":"additional","affiliation":[{"name":"Vascular Biology Program and Department of Surgery Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-7981","authenticated-orcid":false,"given":"Kara L.","family":"Calkins","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology &amp; Developmental Biology Neonatal Research Center of the Children's Discovery and Innovation Institute, David Geffen School of Medicine University of California Los Angeles Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.004770"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e328338c2da"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00233-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.2.9032187"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.03.040"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426506021003279"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616662996"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001121"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000586"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533612439896"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.09.068"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.10.019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b36657"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1463"},{"key":"e_1_2_10_16_1","unstructured":"Omegaven Prescribing Information. 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