{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T17:19:31Z","timestamp":1779988771606,"version":"3.53.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited literature exists on nutrition practices for long\u2010stay patients in the intensive care unit (ICU). We aimed to compare nutrition practices in the first and second weeks of an ICU admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A post hoc exploratory analysis of The Augmented vs Routine Approach to Giving Energy Trial (TARGET) randomized controlled trial (RCT) was undertaken. Inclusion criteria were: enrolled in TARGET on day 1 or 2 of ICU admission and ICU length of stay (LOS) &gt;14 days. Clinical characteristics are described, and nutrition delivery and management compared between days 1\u20137 and 8\u201314. Data are <jats:italic>n<\/jats:italic> (%), mean\u2009\u00b1\u2009SD, median (interquartile range [IQR]), or mean difference (MD) and 95% confidence interval (95% CI), with <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 664 patients were analyzed (56.2\u2009\u00b1\u200916.3 years; 61% male; body mass index 29.2\u2009\u00b1\u20097.5\u2009kg\/m<jats:sup>2<\/jats:sup> and APACHE II 21.9\u2009\u00b1\u20098.1). When comparing days 1\u20137 to 8\u201314: (1) energy delivery was greater (all sources: 1826\u2009\u00b1\u2009603 vs 1729\u2009\u00b1\u2009689 (MD: 97 [95% CI: 52\u2013140]\u2009kcal\/day, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and nonnutrition sources: 317\u2009\u00b1\u2009230 vs 192\u2009\u00b1\u2009197 (MD 125 [95% CI: 111\u2013139]\u2009kcal\/day; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001); (2) protein delivery was similar (66\u2009\u00b1\u200920 vs 68\u2009\u00b1\u200924 (MD: \u22121.4 [95% CI: \u22123.2 to 0.4]\u2009g\/day; <jats:italic>P<\/jats:italic>\u2009=\u20090.125]); and (3) fewer patients received parenteral nutrition (PN) (5% vs 9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) or small intestine feeding (3% vs 8%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this post hoc analysis, patients with an ICU LOS &gt;14 days had greater energy delivery and fewer patients received PN or small intestine feeding during days 1\u20137 than days 8\u201314. Uncertainty remains regarding whether these data reflect usual practice and the clinical implications of this.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2717","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T05:35:12Z","timestamp":1734672912000},"page":"214-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nutrition provision over time in longer stay critically ill patients: A post hoc analysis of The Augmented vs Routine Approach to Giving Energy Trial"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-251X","authenticated-orcid":false,"given":"Elizabeth","family":"Viner Smith","sequence":"first","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"},{"name":"Intensive Care Research Unit Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Lange","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Peake","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"},{"name":"School of Epidemiology and Preventive Medicine Monash University Victoria Australia"},{"name":"The Department of Intensive Care Medicine The Queen Elizabeth Hospital Adelaide Australia"},{"name":"Australian and New Zealand Intensive Care Research Centre Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne J.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"},{"name":"Intensive Care Research Unit Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health The University of Adelaide Adelaide South Australia Australia"},{"name":"Australian and New Zealand Intensive Care Research Centre Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7922-5717","authenticated-orcid":false,"given":"Emma J.","family":"Ridley","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre Monash University Melbourne Victoria Australia"},{"name":"Dietetics and Nutrition Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Rayner","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health The University of Adelaide Adelaide South Australia Australia"},{"name":"Department of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9818-2484","authenticated-orcid":false,"given":"Lee\u2010anne S.","family":"Chapple","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"},{"name":"Intensive Care Research Unit Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health The University of Adelaide Adelaide South Australia Australia"},{"name":"Australian and New Zealand Intensive Care Research Centre Monash University Melbourne Victoria 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