{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:05:35Z","timestamp":1777673135829,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antimicrobial lock therapy is recommended for preventing and treating catheter\u2010related bloodstream infections, but different solutions have uncertain efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two locks, 1.35% taurolidine and 4% ethylenediaminetetraacetic acid (EDTA), were tested on <jats:italic>Staphylococcus epidermidis<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, multidrug\u2010resistant <jats:italic>P. aeruginosa<\/jats:italic>, vancomycin\u2010resistant <jats:italic>Enterococcus faecium<\/jats:italic>, <jats:italic>Klebsiella oxytoca<\/jats:italic> (carbapenemase producing), <jats:italic>K. pneumoniae<\/jats:italic> (extended\u2010spectrum \u03b2\u2010lactamase producing), <jats:italic>Candida albicans<\/jats:italic>, and <jats:italic>Candida glabrata<\/jats:italic>. Broviac catheter segments were incubated with these organisms and then exposed to various lock solutions. Colony\u2010forming units (CFUs) were counted after 2, 4, and 24\u2009h of incubation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Taurolidine showed a significant decrease in CFUs after 2\u2009h in <jats:italic>S. aureus<\/jats:italic>, <jats:italic>S. epidermidis<\/jats:italic>, methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic>, vancomycin\u2010resistant <jats:italic>E. faecium<\/jats:italic>, <jats:italic>P. aeruginosa<\/jats:italic> (both sensitive and multidrug\u2010resistant strains), <jats:italic>K. oxytoca<\/jats:italic>, <jats:italic>C. albicans<\/jats:italic>, and <jats:italic>C. glabrata<\/jats:italic>. After 4\u2009h, significant reductions were noted in <jats:italic>S. aureus<\/jats:italic>, <jats:italic>S. epidermidis<\/jats:italic>, methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic>, <jats:italic>P. aeruginosa<\/jats:italic>, multidrug\u2010resistant <jats:italic>P. aeruginosa<\/jats:italic>, <jats:italic>K. pneumoniae<\/jats:italic>, <jats:italic>K. oxytoca<\/jats:italic>, and <jats:italic>C. albicans<\/jats:italic>. Taurolidine was also effective after 24\u2009h, especially against methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic> and multidrug\u2010resistant <jats:italic>P. aeruginosa<\/jats:italic>. Four percent EDTA acid showed a significant reduction in CFUs after 2\u2009h in <jats:italic>S. aureus<\/jats:italic>, vancomycin\u2010resistant <jats:italic>E. faecium<\/jats:italic>, <jats:italic>P. aeruginosa<\/jats:italic>, <jats:italic>K. oxytoca<\/jats:italic>, <jats:italic>C. albicans<\/jats:italic>, and <jats:italic>C. glabrata<\/jats:italic>. After 4\u2009h, reductions occurred in <jats:italic>P. aeruginosa<\/jats:italic>, multidrug\u2010resistant <jats:italic>P. aeruginosa<\/jats:italic>, <jats:italic>K. oxytoca<\/jats:italic>, and <jats:italic>C. albicans<\/jats:italic> and after 24\u2009h in methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic>, <jats:italic>P. aeruginosa<\/jats:italic>, and <jats:italic>K. oxytoca<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taurolidine is more effective than 4% EDTA acid in eradicating Gram\u2010positive and Gram\u2010negative microorganisms and fungi.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2725","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T04:44:10Z","timestamp":1737866650000},"page":"373-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of taurolidine with 4% ethylenediaminetetraacetic acid on antimicrobial lock effectiveness: An experimental study"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-7899","authenticated-orcid":false,"given":"Jakub","family":"Visek","sequence":"first","affiliation":[{"name":"3rd Department of Internal Medicine\u2014Metabolic Care and Gerontology, University Hospital and Medical Faculty in Hradec Kralove Charles University in Prague Hradec Kralove Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenka","family":"Ryskova","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital and Medical Faculty in Hradec Kralove Charles University in Prague Hradec Kralove Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Cesakova","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital and Medical Faculty in Hradec Kralove Charles University in Prague Hradec Kralove Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Stanclova","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital and Medical Faculty in Hradec Kralove Charles University in Prague Hradec Kralove Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Vajrychova","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre University Hospital Hradec Kralove Hradec Kralove Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Blaha","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine\u2014Metabolic Care and Gerontology, University Hospital and Medical Faculty in Hradec Kralove Charles University in Prague Hradec Kralove Czech 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