{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:12:54Z","timestamp":1791432774690,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Central line\u2013associated bloodstream infections (CLABSIs) are the leading cause of hospitalization in pediatric short bowel syndrome, disproportionately impacting socioeconomically disadvantaged children. We examined changes in overall CLABSI rates over time and assessed whether socioeconomic disparities persist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Pediatric Health Information System database, we studied short bowel syndrome patients aged &lt;18 years hospitalized between 2015 and 2023. Patients were stratified into neighborhood income groups based on zip code\u2013based median household income. CLABSI rates were assessed with mixed\u2010effects Poisson regression over four eras (2016\u20132017, 2018\u20132019, 2020\u20132021, 2022\u20132023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 8772 hospitalizations of 2048 children with short bowel syndrome at 43 institutions, CLABSI was the principal diagnosis for 30% of hospitalizations. Univariable analysis showed decreased CLABSI rates during 2018\u20132019 (rate ratio [RR]\u00a00.71, 95% CI 0.63\u20130.81; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), 2020\u20132021 (RR 0.66, 95% CI 0.57\u20130.75; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and 2022\u20132023 (RR 0.60, 95% CI 0.52\u20130.70; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), relative to 2016\u20132017. In multivariable analyses, 2022\u20132023 was associated with lower CLABSI rates relative to 2016\u20132017 (RR 0.61, 95% CI 0.52\u20130.70; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Low neighborhood income (RR 1.59, 95% CI 1.14\u20132.21; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), public insurance (RR 1.59, 95% CI 1.37\u20131.84; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and non\u2010Hispanic Black race (RR 1.19, 95% CI 1.01\u20131.39; <jats:italic>P<\/jats:italic>\u2009=\u20090.03) were associated with higher CLABSI rates relative to high neighborhood income, private insurance, and non\u2010Hispanic White race, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CLABSI rates in pediatric short bowel syndrome have decreased over the past 8 years, yet socioeconomic and racial disparities persist. Efforts to prevent CLABSI across the socioeconomic spectrum should be prioritized to improve short bowel syndrome outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2766","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T23:19:23Z","timestamp":1745882363000},"page":"572-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Central line\u2013associated bloodstream infection rates in pediatric short bowel syndrome in the United States: A retrospective cohort study from 2016 to 2023"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8625-5837","authenticated-orcid":false,"given":"Susan A.","family":"Gutierrez","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Raghu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-9883","authenticated-orcid":false,"given":"Stephanie B.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Shui","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra L.","family":"Sudan","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke Children's Hospital &amp; Health Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung\u2010Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad I.","family":"Wadhwani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz110"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/657912"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0582"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3642"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/pq9.0000000000000575"},{"issue":"2","key":"e_1_2_9_7_1","first-page":"S14","article-title":"Quality improvement to reduce neonatal CLABSI: the journey to zero","volume":"37","author":"Pearlman SA","year":"2020","journal-title":"Am J Perinatol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1667"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.036"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piu079"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2665"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113819"},{"key":"e_1_2_9_13_1","unstructured":"Pediatric Analytic Solutions. 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