{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:32Z","timestamp":1786978112097,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to determine how the use of parenteral nutrition in late preterm and term infants admitted to the neonatal intensive care unit (NICU) affects outcomes, specifically length of stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective cohort study that included infants \u226535 weeks gestation admitted to a Pediatrix Medical Group\u2013affiliated NICU on day of life 0\u20132 in 2009\u20132019. Propensity score matching was used to control for demographics, delivery characteristics, and severity of illness. Infants were excluded if they received comfort or palliative care in the delivery room or transferred before discharge home. The primary outcome was length of stay. Secondary outcomes were duration of conventional and high\u2010frequency ventilation, late\u2010onset sepsis, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total cohort had 470,433 neonates; of the 259,495 infants who met inclusion criteria and survived to discharge, 97,577 (37.6%) received parenteral nutrition. Of 59,580 propensity\u2010matched neonates comparing parenteral nutrition vs no parenteral nutrition, those receiving parenteral nutrition (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929,790) had a longer median length of stay (10 vs 9 days,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Analysis of secondary outcomes revealed a higher mean number of conventional ventilation days, higher odds of late\u2010onset sepsis, and higher odds of mortality in neonates receiving parenteral nutrition vs no parenteral nutrition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Parenteral nutrition in late preterm and term neonates is associated with increased length of stay, duration of conventional ventilation, and odds of late\u2010onset sepsis and mortality. Prospective clinical trials are needed to better understand the optimal use and timing of parenteral nutrition and associated morbidities in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.2781","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:58:58Z","timestamp":1749185938000},"page":"837-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between parenteral nutrition and length of stay in late preterm and term infants: A retrospective cohort study"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-8764","authenticated-orcid":false,"given":"Katrina A.","family":"Savioli","sequence":"first","affiliation":[{"name":"Department of Pediatrics Uniformed Services University of the Health Sciences Bethesda Maryland USA"},{"name":"Department of Pediatrics Brooke Army Medical Center Fort Sam Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Uniformed Services University of the Health Sciences Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar E.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Biostatistics Consulting Center Uniformed Services University of the Health Sciences Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara H.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Biostatistics Consulting Center Uniformed Services University of the Health Sciences Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7363-4640","authenticated-orcid":false,"given":"Reese H.","family":"Clark","sequence":"additional","affiliation":[{"name":"The Pediatrix Center for Research, Education, Quality, and Safety Sunrise Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-9461","authenticated-orcid":false,"given":"Nicole R.","family":"Dobson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Uniformed Services University of the Health Sciences Bethesda Maryland USA"},{"name":"Division of Newborn Medicine, Department of Pediatrics University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2020.10.008"},{"key":"e_1_2_9_3_1","unstructured":"National Institute for Health and Care Excellence. 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