{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:39:19Z","timestamp":1776724759747,"version":"3.51.2"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Data on pregnancy in patients with Crohn's disease receiving Janus kinase (JAK) inhibitors, with concomitant short bowel syndrome and chronic intestinal failure requiring long\u2010term parenteral support, are extremely limited. We report the case of a patient with refractory Crohn's disease, short bowel syndrome\u2013associated chronic intestinal failure, and long\u2010term home parenteral nutrition who achieved a successful full\u2010term pregnancy while receiving upadacitinib. The 34\u2010year\u2010old woman had a history of severe, treatment\u2010resistant ileocolonic Crohn's disease and multiple intestinal resections, leaving 145 cm of small bowel and resulting in high\u2010output stoma and chronic intestinal failure. After inadequate response to multiple biologics, upadacitinib was initiated with clinical and endoscopic improvement. The patient became pregnant unintentionally while receiving upadacitinib 45 mg daily. Through intensive multidisciplinary management, she achieved clinical remission, stable parenteral support needs, and adequate weight gain and delivered a healthy infant at term. This case illustrates that with close multidisciplinary follow\u2010up, successful pregnancy is possible in patients with chronic intestinal failure and active Crohn's disease receiving parenteral support, even with concurrent exposure to upadacitinib. Further data are needed to assess the safety of JAK inhibitors in pregnancy and to guide care in this complex patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70009","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:35:38Z","timestamp":1757918138000},"page":"1028-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful pregnancy in a patient with active Crohn's disease, chronic intestinal failure, and long\u2010term parenteral nutrition receiving upadacitinib: A case report"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6283-784X","authenticated-orcid":false,"given":"Diana","family":"Coman","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Gastroenterology, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Orlicka","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dane Christina","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2023.07.019"},{"key":"e_1_2_8_3_1","unstructured":"AbbVie. RINVOQ (Upadacitinib) Product Monograph. August 21 2025. Accessed March 6 2025 https:\/\/www.abbvie.ca\/dam\/RINVOQ_PM_EN"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-024-01454-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19557"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izae146"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15136"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00758-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa225"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"1","article-title":"Managing home parenteral nutrition during pregnancy in patient with short bowel syndrome: case report of a successful experience in Sabah, Malaysia","volume":"3","author":"Fiona Fong PW","year":"2022","journal-title":"Front Med Case Rep"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.08.007"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.70009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:19:27Z","timestamp":1762201167000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.70009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,14]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jpen.70009"],"URL":"https:\/\/doi.org\/10.1002\/jpen.70009","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,14]]},"assertion":[{"value":"2025-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}