{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:33:30Z","timestamp":1762202010682,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>For parenteral nutrition (PN)\u2013dependent neonates, soybean oil intravenous lipid emulsions (SO\u2010ILEs) and mixed emulsions (SO, medium\u2010chain triglyceride [MCT], olive oil [OO], and fish oil [FO] ILEs) are likely not providing adequate amounts of key fatty acids (FAs) arachidonic acid (AA) and docosahexaenoic acid (DHA) and are devoid of choline. Current FO\u2010containing ILEs provide excessive amounts of eicosapentaenoic acid (EPA). In neonatal piglets, we compared a novel lipid (NOV\u2010C) with the addition of AA, DHA, and choline while sparing EPA with SO\u2010ILE and SO,MCT,OO,FO\u2010ILE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We compared FA deposition in serum and tissues among groups of neonatal piglets fed exclusive PN based on SO\u2010ILE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097), SO,MCT,OO,FO\u2010ILE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097), or NOV\u2010C (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098). On day 14, serum, liver, lung, brain, retina, and jejunum were collected and FAs in total phospholipid (PL) measured using gas liquid chromatography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total PL, AA was higher for NOV\u2010C compared with SO,MCT,OO,FO\u2010ILE in serum (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003) and all tissues except brain (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.08). DHA was higher for NOV\u2010C and SO,MCT,OO,FO\u2010ILE compared with SO\u2010ILE in the liver (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), jejunum (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and lung (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the retina, DHA was higher for NOV\u2010C compared with SO,MCT,OO,FO\u2010ILE and SO\u2010ILE (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004). EPA was higher for SO,MCT,OO,FO\u2010ILE compared with SO\u2010ILE and NOV\u2010C in serum (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002) and all tissues except brain (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009= 0.48).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with SO\u2010ILE and SO,MCT,OO,FO\u2010ILE, a novel lipid designed to deliver optimal AA, DHA, EPA, and choline for neonates resulted in higher AA and DHA in blood and tissues. The impact on neonatal immune development and key organ functions needs further exploration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70016","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:03:57Z","timestamp":1759046637000},"page":"942-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fatty acid profiles in blood and tissues of parenteral nutrition\u2013fed neonatal piglets using a novel lipid emulsion containing choline"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8700-0035","authenticated-orcid":false,"given":"Mirielle L.","family":"Pauline","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of 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