{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:51:26Z","timestamp":1788565886983,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fatty acids make up a significant portion of brain mass. The choice of lipid injectable emulsion alters a patient's fatty acid profile. In neonates with intestinal failure dependent on parenteral nutrition, this is particularly concerning given their rapid brain development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We randomly assigned 24 infants to receive soy oil lipid emulsion at 1\u2009g\/kg\/day or mixed\u2010oil lipid emulsion containing soy, medium\u2010chain triglyceride, olive, and fish oils at 3\u2009g\/kg\/day. We have previously reported data on intestinal failure\u2013associated liver disease incidence with a 39\u2010day median follow\u2010up. We now report 3\u2010year follow\u2010up, nonprespecified neurodevelopmental screening outcomes using the Ages &amp; Stages Questionnaires\u20103, a test composed of five domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For this follow\u2010up analysis, 20 patients were included, 10 in each group. There was no difference in patient parameters between the groups at birth or screening. The mean\u2009\u00b1\u2009SD peak direct bilirubin was not different between the two groups (soy 1.8\u2009\u00b1\u20091.4\u2009mg\/dl and mixed 1.2\u2009\u00b1\u20090.8\u2009mg\/dl;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.265). There was also no difference when comparing the mean scores or rate of developmental delay for all five Ages &amp; Stages Questionnaire\u20103 domains between treatment groups. There was no correlation between peak direct bilirubin, gestational age, or days of lipid and domain scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this follow\u2010up study of children who had previously received soy oil lipid reduction or a mixed lipid, there was no difference in development at 3 years. Given that this is a secondary outcome from a pilot trial, additional studies powered for developmental differences are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70032","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T04:38:37Z","timestamp":1762835917000},"page":"228-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Developmental outcomes after soybean oil vs mixed\u2010oil intravenous lipid emulsions in neonates: A secondary analysis of a clinical trial"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8646-8402","authenticated-orcid":false,"given":"Katie A.","family":"Huff","sequence":"first","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine Indianapolis Indiana USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio 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