{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:43:29Z","timestamp":1785019409155,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Heparin is frequently infused in neonatal central venous catheters to prevent occlusion during parenteral nutrition despite limited evidence of its effectiveness and potential safety concerns in preterm infants. This study evaluated the incidence of catheter occlusion in epicutaneo\u2010caval catheters managed without heparin in a large neonatal cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a descriptive cohort study including all neonates admitted to the neonatal intensive care unit who required epicutaneo\u2010caval catheters placement for parenteral nutrition. No heparin was added to infusions. Data were collected on catheter characteristics, insertion parameters, and reasons for removal. The primary outcome was the incidence of catheter occlusion per 1000 catheter\u2010days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 357 neonates with 357 epicutaneo\u2010caval catheters were analyzed, representing 4007 catheter\u2010days. Mean\u2009\u00b1\u2009SD gestational age was 29\u2009\u00b1\u20094.1 weeks, and mean\u2009\u00b1\u2009SD birthweight was 1050\u2009\u00b1\u2009797\u2009g. The mean\u2009\u00b1\u2009SD catheter dwell time was 11.2\u2009\u00b1\u20097.7 days. Most catheter insertions occurred in the upper extremities (92.7%), with prematurity being the most common indication (53.7%). Catheter removal was elective in 67.5% of cases. Only three occlusions were reported, corresponding to 0.7% of catheters and 0.76 occlusions per 1000 catheter\u2010days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates a low rate of epicutaneo\u2010caval catheters occlusion in neonates receiving parenteral nutrition without heparin infusion. These findings support the safety and feasibility of a heparin\u2010free approach in neonatal central catheter management when standardized care protocols are followed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70037","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:14:59Z","timestamp":1765599299000},"page":"247-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epicutaneo\u2010caval catheter occlusion in neonates without heparin infusion during parenteral nutrition: A descriptive cohort study"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-799X","authenticated-orcid":false,"given":"Vito","family":"D'Andrea","sequence":"first","affiliation":[{"name":"Neonatology Unit, Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Prontera","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Monachini","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Cerreti","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS Rome 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