{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:02:35Z","timestamp":1789488155612,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ2400125"],"award-info":[{"award-number":["GJJ2400125"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiovascular diseases remain the leading cause of global mortality, and serum 25\u2010hydroxyvitamin D (25(OH)D) deficiency has been identified as a potential contributing risk factor. The American Heart Association introduced Life's Essential 8, a comprehensive framework comprising eight core metrics for assessing cardiovascular health. However, current evidence on the association between serum 25(OH)D status and Life's Essential 8 score remains limited, particularly regarding potential nonlinear relationships. Therefore, this study aims to examine the association between serum 25(OH)D levels and cardiovascular health measured by Life's Essential 8 score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional analysis of 17,198 adults using data from the National Health and Nutrition Examination Survey 2007\u20132018. Life's Essential 8 score were calculated following standardized protocols. Statistical analyses included multivariable logistic regression, restricted cubic spline models, and mediation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our analysis revealed a significant nonlinear association between serum 25(OH)D levels and Life's Essential 8 score, with an optimal threshold observed at approximately 127\u2009nmol\/L (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.05,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). This association persisted after adjusting for traditional cardiovascular risk factors (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Mediation analysis indicated that uric acid mediates approximately 7% of the indirect effect of the relationship between serum 25(OH)D and cardiovascular health. The results indicate that serum 25(OH)D status is associated with cardiovascular health both in direct and indirect effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates a significant association between serum 25(OH)D levels and cardiovascular health, as quantified by Life's Essential 8 score. These findings emphasize the significance of optimal vitamin D supplementation being inversely related to CVD risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70075","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:45:32Z","timestamp":1773812732000},"page":"557-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between serum 25(OH)D and Life's Essential 8 score: A cross\u2010sectional study"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6650-0477","authenticated-orcid":false,"given":"Xingyu","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 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