{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:54:45Z","timestamp":1785772485665,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to assess the incidence and identify risk factors associated with the development of propofol\u2010induced hypertriglyceridemia in critically ill trauma patients who required nutrition therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients (aged &gt;17 years) admitted to the trauma intensive care unit who received propofol for &gt;24\u2009h and had a serum triglyceride concentration determination during the infusion were retrospectively evaluated. Hypertriglyceridemia was defined as a serum triglyceride concentration &gt;\u2009400\u2009mg\/dL. Potential risk factors for hypertriglyceridemia as well as linear and nonlinear correlative relationships between propofol\u2010associated lipid injectable emulsion dose and serum triglyceride concentration were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and ninety\u2010five serum triglyceride determinations were obtained from 100 patients. Twenty\u2010five patients (25%) developed hypertriglyceridemia. The greatest risk factor for hypertriglyceridemia was lipid injectable emulsion dose (0.48 [0.36, 0.64] vs 0.28 [0.20, 0.49] g\/kg\/day;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Those who exhibited hypertriglyceridemia had a higher C\u2010reactive protein (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.02), lower prealbumin (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), higher serum creatinine (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.04), and required more days of nutrition therapy (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.03). The hypertriglyceridemia group exhibited a nonlinear concave lipid dose\u2013serum triglyceride concentration response relationship (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.731,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) whereas those without hypertriglyceridemia had a flattened and variable linear relationship (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.115,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.34).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypertriglyceridemia is common during propofol therapy, reflective of lipid injectable emulsion dose, and is associated with greater inflammation, organ dysfunction, and severe critical illness requiring prolonged nutrition therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70105","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:43:46Z","timestamp":1779011026000},"page":"794-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Propofol\u2010induced hypertriglyceridemia in critically ill trauma patients requiring nutrition therapy: A descriptive cohort study"],"prefix":"10.1002","volume":"50","author":[{"given":"Emma S.","family":"Lemke","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"TriStar Horizon Medical Center Dickson Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon K.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"St Bernard's Regional Medical Center Jonesboro Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E.","family":"Farrar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskya","family":"Byerly","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina M.","family":"Filiberto","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-6317","authenticated-orcid":false,"given":"Roland N.","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001432"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006574"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(79)90089-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2688-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.10.1348"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202407-781OC"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10600280241232991"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202205-403OC"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426596011004147"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/088453360101600502"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607189013006614"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(96)00386-3"},{"issue":"5","key":"e_1_2_8_14_1","first-page":"641","article-title":"Cholestasis caused by lipid emulsions","volume":"154","author":"Allardyce DB","year":"1982","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000282"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-197403000-00001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003299"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2721"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614542439"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10546"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004124"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614530763"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.060963"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200203000-00006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000059724.08290.51"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.06.003"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198605000-00009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198211000-00008"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198709000-00005"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860718000400514"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0696-6"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318256de1b"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M626"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000037"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028853"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.70105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpen.70105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.70105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:06:26Z","timestamp":1785769586000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.70105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jpen.70105"],"URL":"https:\/\/doi.org\/10.1002\/jpen.70105","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,17]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}