{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:54:45Z","timestamp":1785772485617,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malnutrition is common in older patients with heart failure and predicts poor outcomes. However, the prognostic value of assessing muscle function and fat stores alongside GLIM remains unclear. We therefore tested whether assessing handgrip strength and fat mass index alongside GLIM improves risk stratification for mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a post hoc analysis of patients \u226565 years in the multicenter observational FRAGILE\u2010HF cohort. Malnutrition was evaluated using GLIM criteria at hospital discharge. Handgrip strength and fat mass index were also measured at discharge; low handgrip strength was defined as &lt;28\u2009kg in men and &lt;18\u2009kg in women, and low fat mass index as &lt;4.62\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      in men and &lt;5.86\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      in women. Patients were classified into four groups by GLIM\u2010defined malnutrition and low handgrip strength and, separately, by GLIM\u2010defined malnutrition and low fat mass index. Associations with 2\u2010year all\u2010cause mortality were examined using Cox proportional hazards regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1332 patients, 834 were analyzed (median age, 81 years; 57.6% men). In four\u2010group analyses, GLIM\u2010defined malnutrition with low handgrip strength (HR, 2.06; 95% CI, 1.14\u20133.73;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) and GLIM\u2010defined malnutrition with low fat mass index (HR, 1.87; 95% CI, 1.25\u20132.80;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) had higher mortality than the corresponding reference groups (absence of malnutrition with normal handgrip strength and absence of malnutrition with normal fat mass index).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Assessing handgrip strength or fat mass index alongside GLIM identified subgroups at higher risk of 2\u2010year mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70110","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:11:19Z","timestamp":1780474279000},"page":"823-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined GLIM\u2010defined malnutrition and sarcopenia and the risk of 2\u2010year mortality in adults with heart failure: A FRAGILE\u2010HF study post hoc analysis"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3076-4824","authenticated-orcid":false,"given":"Koji","family":"Matsuo","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences Kitasato University Graduate School of Medical Sciences Sagamihara Japan"},{"name":"Department of Rehabilitation Sagamihara Kyodo Hospital Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7706-9511","authenticated-orcid":false,"given":"Kentaro","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences Kitasato University Graduate School of Medical Sciences Sagamihara Japan"},{"name":"Department of Rehabilitation, School of Allied Health Sciences Kitasato University Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Department of Cardiology Osaka Medical and Pharmaceutical University Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Hamazaki","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Kitasato University Hospital Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences Kitasato University Graduate School of Medical Sciences Sagamihara Japan"},{"name":"Department of Rehabilitation Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4680-1068","authenticated-orcid":false,"given":"Masashi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences Kitasato University Graduate School of Medical Sciences Sagamihara Japan"},{"name":"Division of Research, ARCE Inc. 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