{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:54:33Z","timestamp":1785772473124,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital diaphragmatic hernia is a critical neonatal condition frequently associated with growth impairment. Nutritional strategies to support adequate growth remain poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the association between caloric and protein intake, timing of parenteral and enteral nutrition, and changes in anthropometric\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores during neonatal hospitalization in infants with congenital diaphragmatic hernia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective cohort study including infants with congenital diaphragmatic hernia who underwent surgical repair at a single center between 2018 and 2023. Data were collected from birth to discharge or 12th week of hospitalization. Weekly deltas in anthropometric\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores\u2014weight\u2010for\u2010age, length\u2010for\u2010age, and head circumference\u2010for\u2010age\u2014were calculated. Daily caloric and protein intakes were estimated and averaged weekly; timing of parenteral and enteral nutrition and disease\u2010related factors were obtained and associations with anthropometric\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score deltas were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 117 infants were included. Overall, 65% experienced\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score declines \u22650.8 across all anthropometric\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores. Receiver operating characteristic (ROC) curve analysis identified a caloric intake of 113\u2009kcal\/kg\/day as predictive of positive weight\u2010for\u2010age\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score deltas (area under curve 0.67) with improved specificity at 118\u2009kcal\/kg\/day. In multivariable linear mixed\u2010effects model, higher caloric intake (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and longer duration of mechanical ventilation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) were independently associated with positive weekly weight\u2010for\u2010age\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score deltas. Additionally, higher caloric intake was independently associated with positive weekly head circumference\u2010for\u2010age\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score deltas (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Growth impairment during hospitalization was highly prevalent among infants with congenital diaphragmatic hernia. A caloric intake of at least 113\u2009kcal\/kg\/day, with an optimal threshold near 118\u2009kcal\/kg\/day, may help prevent further deterioration in weight status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70111","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:15:11Z","timestamp":1780474511000},"page":"864-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between nutritional intakes and growth trajectories among infants with congenital diaphragmatic hernia: A retrospective cohort study"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8503-6572","authenticated-orcid":false,"given":"Grisell","family":"Villarreal","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-8065","authenticated-orcid":false,"given":"Mat\u00edas","family":"Luco","sequence":"additional","affiliation":[{"name":"Department of Neonatology, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4488-8753","authenticated-orcid":false,"given":"Valeria","family":"De Toro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago 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