{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:56:22Z","timestamp":1791197782278,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malnutrition is an independent risk factor for postoperative complications\u2014particularly surgical site infections\u2014and recovery delays following colorectal surgery. While some evidence suggests perioperative nutritional interventions have the potential to decrease complication rates, this literature is heterogeneous with difficult to control implementation barriers. We conducted a systematic review and meta\u2010analysis to appraise available evidence regarding perioperative nutritional interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched Medline, Embase, CAB Abstracts, and CINAHL between 2000 and 2023 for studies assessing perioperative protein supplementation, immunonutrition, carbohydrate loading, and postoperative diet progression in colorectal surgery patients. Individual study risk of bias and overall strength of evidence (SOE) were evaluated using standardized methods. We used random\u2010effects modeling for meta\u2010analyses of study\u2010level data when \u22653 studies were available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010seven eligible studies underwent data extraction. Ten were low\/moderate risk of bias. Compared to dietary advice alone, protein supplementation and immunonutrition may show a benefit in lower surgical site infection rates, and carbohydrate loading may result in no difference (all low SOE). Both immunonutrition and carbohydrate loading probably do not impact anastomotic leak rates (moderate SOE). Immunonutrition and carbohydrate loading may result in no length of stay differences (low SOE). Evidence was insufficient assessing the optimal diet immediately following surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perioperative colorectal surgery nutrition interventions are heterogeneous with current evidence suggesting small to negligible benefits regarding postoperative complications. No studies comparing low\u2010fiber diet to regular diet met inclusion criteria. The majority of evidence is insufficient, highlighting research opportunities to further enhance nutritional optimization and limit complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70112","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:11:38Z","timestamp":1781586698000},"page":"920-937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative nutrition therapy to optimize colorectal patient outcomes: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-5814","authenticated-orcid":false,"given":"Alexander","family":"Troester","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Colon &amp; Rectal Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5726-929X","authenticated-orcid":false,"given":"Shelbi","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Colon &amp; Rectal Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Welton","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Colon &amp; Rectal Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-2967","authenticated-orcid":false,"given":"Lauren","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Colon &amp; Rectal Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6087-0583","authenticated-orcid":false,"given":"Romil","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Health Policy &amp; Management, School of Public Health University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Colon &amp; Rectal Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Claussen","sequence":"additional","affiliation":[{"name":"Division of Health Policy &amp; Management, School of Public Health University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7346-8048","authenticated-orcid":false,"given":"Sallee","family":"Brandt","sequence":"additional","affiliation":[{"name":"Division of Health Policy &amp; Management, School of Public Health University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Butler","sequence":"additional","affiliation":[{"name":"Division of Health Policy &amp; Management, School of Public Health University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-2671","authenticated-orcid":false,"given":"Bronwyn","family":"Southwell","sequence":"additional","affiliation":[{"name":"Department of Anesthesia University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Goffredo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Colon &amp; Rectal Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.09.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.03.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112440285"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13061980"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.05.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181e9819a"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.148619"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003704"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3465-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.13570"},{"key":"e_1_2_9_12_1","unstructured":"Joint Commission Center for Transforming Healthcare and American College of Surgeons Collaborative. 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