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Key enteral nutrition\u2010related considerations include: the unique anatomy and physiology of the gastrointestinal tract, altered metabolic capacity, availability of maternal milk and use of alternative substrates, detailed methods of initiation and advancement of enteral feeding, methods of human milk fortification, targeted requirements for macronutrient and micronutrients, and the safety and efficacy of enteral nutrition support management to optimize the growth and development of the nano\u2010preterm infant. This comprehensive review focused on enteral nutrition provision in nano\u2010preterm infants, thoroughly evaluating available literature and identifying knowledge gaps about the unique physiology and metabolism of the nano\u2010preterm infant as it pertains to enteral nutrition. Ultimately, prospective multicenter research is needed to establish evidence\u2010based guidelines to promote optimal growth and development while minimizing complications of extreme prematurity.<\/jats:p>","DOI":"10.1002\/jpen.70133","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:26:08Z","timestamp":1785752768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of current enteral nutrition support recommendations to infants born less than 750 grams or less than 25 weeks' gestation: A critical review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-7786","authenticated-orcid":false,"given":"Mar","family":"Romero\u2010Lopez","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Perinatal\u2010Neonatal Medicine, University of Texas Health Science Center Houston, McGovern Medical School Houston Texas 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