{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:55:16Z","timestamp":1791197716216,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Constipation is a common complication in critically ill patients and has been associated with adverse clinical outcomes. However, the role of enteral nutrition composition, particularly fiber and fluid administration, remains unclear. The aim of this study was to evaluate the association between dietary fiber and fluid administration and constipation in invasive mechanical ventilated critically ill adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective cohort study including 74 critically ill adults requiring invasive mechanical ventilation and enteral nutrition. Patients were followed for up to 144\u2009h from initiation of mechanical ventilation. Fiber and total fluid administration were evaluated as time\u2010varying exposures. Constipation was defined as absence of defecation within 144\u2009h. Discrete\u2010time survival analysis was used to assess associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Constipation occurred in 54% of patients. Time to first defecation ranged from 48 to 504\u2009h. Most patients (97.3%) received early enteral nutrition, although fiber and fluid delivery were frequently below guideline\u2010recommended targets. No significant association was observed between fiber intake or fluid administration and constipation after adjustment, with results expressed as odds ratios (ORs) and 95% confidence intervals (CIs) (fiber: OR = 1.17, 95% CI: 0.41\u20133.38; fluids: OR = 1.40, 95% CI: 0.29\u20136.84).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In critically ill patients receiving invasive mechanical ventilation, fiber and fluid administration were not associated with constipation. These findings may reflect limited exposure during the early phase of critical illness, when gastrointestinal dysfunction is more strongly influenced by disease severity and pharmacological factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70137","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:10:33Z","timestamp":1787116233000},"page":"976-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fiber and fluid administration and the risk of constipation in critically ill adults on mechanical ventilation: A prospective cohort study"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-7574","authenticated-orcid":false,"given":"Paola Renata","family":"Lamoyi\u2010Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\u00f3n Cl\u00ednica Instituto Nacional de Enfermedades Respiratorias Ciudad de Mexico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-0937","authenticated-orcid":false,"given":"Nadia Carolina","family":"Rodr\u00edguez\u2010Moguel","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n Cl\u00ednica Instituto Nacional de Enfermedades Respiratorias Ciudad de Mexico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes Guadalupe","family":"Pedroza\u2010Ter\u00e1n","sequence":"additional","affiliation":[{"name":"Servicio de Broncoscop\u00eda y Endoscop\u00eda, Instituto Nacional de Enfermedades Respiratorias Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-923X","authenticated-orcid":false,"given":"Lilia","family":"Castillo\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Servicio de Nutriolog\u00eda Cl\u00ednica, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-8953","authenticated-orcid":false,"given":"Sebastian","family":"Rodr\u00edguez\u2010Llamazares","sequence":"additional","affiliation":[{"name":"Division of Respirology and Sleep Medicine Queen's University Kingston Ontario Canada"},{"name":"Kingston Health Sciences Center Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josue Daniel","family":"Cadeza\u2010Aguilar","sequence":"additional","affiliation":[{"name":"Departamento de \u00c1reas Cr\u00edticas Instituto Nacional de Enfermedades Respiratorias Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-2978","authenticated-orcid":false,"given":"Carmen Margarita","family":"Hern\u00e1ndez\u2010Cardenas","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n General, Instituto Nacional de Enfermedades Respiratorias Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3490-3414","authenticated-orcid":false,"given":"Iv\u00e1n Armando","family":"Osuna\u2010Padilla","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n Cl\u00ednica Instituto Nacional de Enfermedades Respiratorias Ciudad de Mexico 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