{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T12:12:02Z","timestamp":1788696722857,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatohepatitis (MASH) is associated with altered intestinal permeability, allowing microbial products to translocate to the liver via the enterohepatic circulation and contributes to disease progression. The aim of our study was to evaluate the association between probiotic supplementation and serum claudin\u20103 levels in patients with MASH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a secondary analysis of a randomized, double\u2010blind, placebo\u2010controlled trial including adult outpatients with biopsy\u2010confirmed MASH (Activity Score &gt;4). Participants received either a probiotic mixture (\n                      <jats:italic>Lactobacillus acidophilus, L. rhamnosus, L. paracasei, Bifidobacterium animalis subsp. lactis; 1<\/jats:italic>\n                      \u2009\n                      <jats:italic>\u00d7<\/jats:italic>\n                      \u2009\n                      <jats:italic>\n                        10\n                        <jats:sup>9<\/jats:sup>\n                        CFU\n                      <\/jats:italic>\n                      or placebo (2 sachets\/day) for 24 weeks. Serum claudin\u20103 levels and dietary intake were assessed before and after the intervention. Changes were analyzed using Generalized Estimating Equations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010four patients completed the trial. Baseline claudin\u20103 concentrations were similar between groups. After 24 weeks, serum claudin\u20103 levels significantly decreased in both the probiotic (14.7 to 6.1\u2009ng\/mL) and placebo groups (16.7 to 6.0\u2009ng\/mL), with no significant between\u2010group difference. Both groups reported reduced intake of calories, carbohydrates, proteins, and fats, but no differences in weight or waist circumference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, serum claudin\u20103 levels decreased significantly over the 24\u2010week study period in patients with MASH. However, probiotic supplementation did not result in additional reductions in intestinal permeability compared to placebo.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70144","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T11:39:37Z","timestamp":1788694777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Probiotics and intestinal permeability in adults with metabolic dysfunction\u2010associated steatohepatitis: A secondary analysis of a randomized clinical trial"],"prefix":"10.1002","author":[{"given":"Bruna Concheski","family":"de Moura","sequence":"first","affiliation":[{"name":"Graduate Program: Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6240-8488","authenticated-orcid":false,"given":"Samanta Catherine","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Graduate Program in Food, Nutrition, and Health, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-1003","authenticated-orcid":false,"given":"Amanda Souza","family":"Silva\u2010Sperb","sequence":"additional","affiliation":[{"name":"Graduate Program: Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Abadie","family":"Moraes","sequence":"additional","affiliation":[{"name":"Graduate Program: Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisse","family":"Longo","sequence":"additional","affiliation":[{"name":"Graduate Program: Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Experimental Laboratory of Hepatology and Gastroenterology Center for Experimental Research, Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Uribe\u2010Cruz","sequence":"additional","affiliation":[{"name":"Graduate Program: Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Experimental Laboratory of Hepatology and Gastroenterology Center for Experimental Research, Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Truccolo","family":"Michalczuk","sequence":"additional","affiliation":[{"name":"Graduate Program: Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Themis Reverbel da","family":"Silveira","sequence":"additional","affiliation":[{"name":"Experimental Laboratory of Hepatology and Gastroenterology Center for Experimental Research, Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Thadeu Schmidt","family":"Cerski","sequence":"additional","affiliation":[{"name":"Graduate Program: Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Unit of Surgical Pathology, Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio Reis \u00c1lvares da","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate Program: Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul Porto Alegre 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