{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:49:44Z","timestamp":1791791384284,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intestinal failure patients receiving home parenteral nutrition are at risk of catheter\u2010related bloodstream infection. Metastatic infections include infective endocarditis and vertebral osteomyelitis. We aimed to investigate the incidences of catheter\u2010related bloodstream infection, infective endocarditis, and vertebral osteomyelitis in type 3 intestinal failure patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cohort study conducted in a Danish referral intestinal failure center. All data on catheter\u2010related bloodstream infections, infective endocarditis, and vertebral osteomyelitis were retrieved from medical records on patients receiving home parenteral nutrition through tunneled cuffed central venous access devices or peripherally inserted central catheters from 01 January 2019 to 31 December 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 323 patients (209 females) were included, totaling 913 catheters and 293,650 catheter days. The catheter\u2010related bloodstream infection incidence was 0.93 per 1,000 catheter days (95% CI: 0.82\u20131.03) over the 5\u2010year period, with a statistically significantly higher incidence for tunneled cuffed central venous access devices than for peripherally inserted central catheters (1.10 [95% CI: 0.95\u20131.26] vs. 0.66 [95% CI: 0.52\u20130.81] per 1,000 catheter days, respectively). Thirteen cases of infective endocarditis (0.04 per 1,000 catheter days [95% CI: 0.02\u20130.07]) and ten cases of vertebral osteomyelitis (0.03 per 1000 [95% CI: 0.01\u20130.06]) were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The catheter\u2010related bloodstream infection incidence is within the acceptable range recommended by current guidelines. The incidence of infective endocarditis is higher, and that of vertebral osteomyelitis is similar to those in other studies. Catheter\u2010related bloodstream infection is a serious complication that may lead to infective endocarditis or vertebral osteomyelitis, underscoring the need for timely detection and management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.70152","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:38:48Z","timestamp":1791790728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catheter\u2010related bloodstream infections, infective endocarditis, and vertebral osteomyelitis in adults receiving home parenteral nutrition: A descriptive cohort study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1455-410X","authenticated-orcid":false,"given":"Selma Maria","family":"Boltz\u2010Jensen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Center for Nutrition and Intestinal Failure, Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2556-811X","authenticated-orcid":false,"given":"Jakob M\u00f8ller","family":"Vandb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Center for Nutrition and Intestinal Failure, Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4319-6873","authenticated-orcid":false,"given":"Abina","family":"Mohanaraj","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Center for Nutrition and Intestinal Failure, Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6608-5548","authenticated-orcid":false,"given":"Sofie Kibsgaard","family":"Dall","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Center for Nutrition and Intestinal Failure, Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-5992","authenticated-orcid":false,"given":"Charlotte Lock","family":"Rud","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-223X","authenticated-orcid":false,"given":"Janne","family":"Fassov","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik H\u00f8jgaard","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Center for Nutrition and Intestinal Failure, Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"The Dietitians and Nutritional Research Unit, EATEN Copenhagen University Hospital Herlev and Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0251-6049","authenticated-orcid":false,"given":"Jakob Lykke","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Center for Nutrition and Intestinal Failure, Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-7184","authenticated-orcid":false,"given":"Christian Lodberg","family":"Hvas","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Vinter\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 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