{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:05:03Z","timestamp":1785816303400,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study to evaluate the contributions of titanium\u2010prepared platelet\u2010rich fibrin (T\u2010PRF) combined with open flap debridement (OFD) on biological markers in gingival crevicular fluid (GCF)and periodontal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010nine participants with chronic periodontitis were treated either with autologous T\u2010PRF+OFD or OFD alone. GCF growth factor levels and relative receptor activator nuclear factor kappa\u2010B\/osteoprotegerin (RANKL\/OPG) ratio at baseline and 2, 4, and 6\u00a0weeks postoperatively were analyzed, and clinical parameters such as probing depth (PD), relative attachment level (RAL) and gingival margin level (GML) at baseline and 9 months after surgery were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean PD reduction, RAL gain, and GML change were significantly greater in the OFD+T\u2010PRF sites than in the OFD sites (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.033, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.029, and <jats:italic>P\u00a0<\/jats:italic>=\u00a00.026, respectively). Both groups demonstrated increased growth factor levels at week 2 compared with baseline, followed by reductions at weeks 4 and 6. GCF growth factor levels in the test group were seen at higher concentrations with respect to control group until 6\u00a0weeks post\u2010surgery. During this 6\u2010week period, relative RANKL\/OPG ratio was found significantly lower in the OFD+T\u2010PRF group compared to the OFD group(<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using T\u2010PRF membrane combined with OFD provided significantly higher concentrations of growth factors and lower RANKL\/OPG ratio in GCF for approximately 4 to 6\u00a0weeks, and improved periodontal healing compared to conventional flap sites.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0294","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T07:23:46Z","timestamp":1518420226000},"page":"255-264","source":"Crossref","is-referenced-by-count":22,"title":["Titanium\u2010prepared platelet\u2010rich fibrin provides advantages on periodontal healing: A randomized split\u2010mouth clinical study"],"prefix":"10.1002","volume":"89","author":[{"given":"Taner","family":"Arabaci","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mevlut","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Medical Laboratory Department Health Services Vocational Training School Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12114"},{"key":"e_1_2_8_3_1","first-page":"43","article-title":"Clinical evaluation of autologous platelet rich fibrin in horizontal alveolar bony defects","volume":"8","author":"Joseph VR","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_8_4_1","first-page":"185","article-title":"Regenerative periodontal therapy","volume":"45","author":"H\u00e4gi TT","year":"2014","journal-title":"Quintessence Int"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150314"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"Application of platelet\u2010rich plasma with stem cells in bone and periodontal tissue engineering","volume":"13","author":"Fernandes G","year":"2016","journal-title":"Bone Res"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12352"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12644"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00432.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.6.849"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00640.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.11.032"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.12.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02274.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160058"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.04.053"},{"key":"e_1_2_8_18_1","first-page":"338","article-title":"Effect of various fibrin preparations on reimplantations in the rat skin (in German)","volume":"67","author":"Matras H","year":"1970","journal-title":"Osterr Z Stomatol"},{"key":"e_1_2_8_19_1","first-page":"529","article-title":"Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants","volume":"4","author":"Anitua E","year":"1999","journal-title":"Int J Oral Maxillofac Imp"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008505-200110000-00002"},{"key":"e_1_2_8_21_1","first-page":"55","article-title":"An opportunity in perio\u2010implantology: the PRF (in French)","volume":"42","author":"Choukroun J","year":"2001","journal-title":"Implantodontie"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090252"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.1826"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2015.1035672"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12040"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/cap.2011.110034"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2008.11.009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.03.017"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/209548"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.09.092"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.03.016"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2012.08.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_8_34_1","first-page":"107","article-title":"Gingival sulcus bleeding \u2013 A leading symptom in initial gingivitis","volume":"15","author":"Muhlemann HR","year":"1971","journal-title":"Helv Odontol Acta"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.16-0212"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12354"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027009698.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02463.x"},{"key":"e_1_2_8_39_1","first-page":"128XM 307CS","article-title":"Characterization of autologous growth factors in cascade platelet rich fibrin matrix (PRFM). Edison, NJ:","author":"Carroll RJ","year":"2005","journal-title":"Musculoskeletal Transplant Foundation"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01701.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01065.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01094.x"},{"key":"e_1_2_8_43_1","first-page":"197","article-title":"Comparative investigation of the effects of titanium prepared platelet\u2010rich fibrin (T\u2010PRF) and platelet\u2010rich fibrin (PRF) on new bone formation","volume":"24","author":"F\u0131ratl\u0131 E","year":"2013","journal-title":"Clin Oral Imp Res"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.115663"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdj.2012.10.003"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100731"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01446.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.5.757"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.0416"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJPER.17-0294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.17-0294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:22:16Z","timestamp":1760869336000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.17-0294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/JPER.17-0294"],"URL":"https:\/\/doi.org\/10.1002\/jper.17-0294","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}