{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:48:38Z","timestamp":1767865718230,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peri\u2010implant infections are associated with the establishment and maturation of a bacterial biofilm characterized by a predominance of Gram\u2010negative fusiform anaerobic species. The decontamination of implant surfaces is then crucial for a successful peri\u2010implant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one smooth and 21 rough implants, divided into four groups according to surface and treatment modality, were contaminated with <jats:italic>Streptococcus sanguinis<\/jats:italic> and then placed in an incubator with the atmosphere of 5% CO2 at 37\u00b0C for 24\u00a0hours to allow the bacteria to grow. After 24\u00a0hours, the test groups were treated with controlled release 14% doxycycline gel injecting the gel circumferentially over the surface of the implant for 3 minutes, while the control groups were irrigated with sterile saline for 1 minute. The implants were then vortexed into triptych soy broth to allow the bacteria to detach from the surface, diluted 1:100 and plated. Colony forming units (CFU) were counted 48\u00a0hours after incubation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of a 14% doxycycline gel minimized CFU counts compared to control groups, with the difference being statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The reduction of CFUs in the smooth test group is more marked than in the rough test group, but the difference doesn't reach statistically significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.215).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of 14% doxycycline gel in implant surface decontamination was efficacious in this in\u2010vitro study. Adjunctive use of locally delivered 14% doxycycline gel might be a viable option in the management of peri\u2010implantitis and peri\u2010implant mucositis considering its efficacy in reducing bacterial colonization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0325","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T08:04:56Z","timestamp":1519286696000},"page":"325-330","source":"Crossref","is-referenced-by-count":24,"title":["In vitro evaluation of controlled\u2010release 14% doxycycline gel for decontamination of machined and sandblasted acid\u2010etched implants"],"prefix":"10.1002","volume":"89","author":[{"given":"Giuseppe","family":"Patianna","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Implantology Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola Alberto","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of Surgery Geneva University Hospitals, University of Geneva, Unit of Oral Surgery and Implantology, Service of Maxillofacial and Buccal Surgery  Geneva Switzerland"},{"name":"Department of Periodontics and Endodontics State University of New York at Buffalo  Buffalo NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"D'Addona","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implantology Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"Andreana","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry State University of New York at Buffalo  Buffalo NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2006.00019.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(81)80077-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(86)80010-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00387.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2016.46.3.136"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Microbiome and microbial biofilm profiles of peri\u2010implantitis: a systematic review","author":"Lafaurie GI","year":"2017","journal-title":"J Periodontol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01274.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1999.100501.x"},{"key":"e_1_2_8_10_1","first-page":"106","article-title":"Microbial findings of deep peri\u2010implant bone defects","volume":"12","author":"Augthun M","year":"1997","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.160751"},{"key":"e_1_2_8_12_1","first-page":"169","article-title":"The influence of titanium abutment surface roughness on plaque accumulation and gingivitis: short\u2010term observations","volume":"11","author":"Quirynen M","year":"1996","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb01077.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070302.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.6.556"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g5.3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12049"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12224"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290204.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.1.66"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1979.tb02186.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.11s.93"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12398"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01127.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120012701"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080574"},{"key":"e_1_2_8_27_1","first-page":"381","article-title":"Treatment of furcation defects with an allograft\u2010alloplast\u2010tetracycline composite bone graft combined with GTR: human histologic evaluation of a case report","volume":"22","author":"Harris RJ","year":"2002","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_28_1","first-page":"338","article-title":"Reduced corrosion of CP Ti and Ti\u20106A1\u20104V alloy endosseous dental implants after glow\u2010discharge treatment: a preliminary report","volume":"7","author":"Vargas E","year":"1992","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2016.4247"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.11.1292"},{"key":"e_1_2_8_31_1","first-page":"706","article-title":"Antimicrobial efficacy of semiconductor laser irradiation on implant surfaces","volume":"18","author":"Kreisler M","year":"2003","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000597"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12735"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2016.7313"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01277.x"},{"key":"e_1_2_8_36_1","first-page":"321","article-title":"In vivo plaque formation on implant materials","volume":"4","author":"Nakazato G","year":"1989","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000154793.84609.2c"},{"key":"e_1_2_8_38_1","first-page":"27","article-title":"A study of in vitro attachment of Streptococcus sanguis and Actinomyces viscosus to saliva\u2010treated titanium","volume":"4","author":"Wolinsky LE","year":"1989","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.120601.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000067"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3703"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02256.x"},{"key":"e_1_2_8_43_1","first-page":"536","article-title":"Oral implant surfaces: part 1\u2013review focusing on topographic and chemical properties of different surfaces and in vivo responses to them","volume":"17","author":"Albrektsson T","year":"2004","journal-title":"Int J Prosthodont"},{"issue":"1","key":"e_1_2_8_44_1","first-page":"S52","article-title":"Immediate occlusal loading of Branemark System TiUnite implants placed predominantly in soft bone: 4\u2010year results of a prospective clinical study","volume":"7","author":"Glauser R","year":"2005","journal-title":"Clin Implant Dent Relat Res"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2005.tb00055.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2007.00060.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02255.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01661.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/159625"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJPER.17-0325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.17-0325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:22:18Z","timestamp":1760869338000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.17-0325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/JPER.17-0325"],"URL":"https:\/\/doi.org\/10.1002\/jper.17-0325","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,28]]}}}