{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:46:35Z","timestamp":1770039995564,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have proven the existence of herpesviruses in periodontal pockets of patients with chronic or aggressive periodontitis. Recently discovered interferon lambda (IFN\u2010\u03bb) has antiviral properties and is induced by herpesviruses. The present study was a quantitative analysis of messenger RNA (mRNA) expression of IFN\u2010\u03bbs (IFN\u2010\u03bb1, IFN\u2010\u03bb2, IFN\u2010\u03bb3) in the gingival tissues of patients with chronic or aggressive periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 90 participants (50 men and 40 women; age range 19\u201350 years, mean age 31.50 \u00b1 7.8) were categorized into three groups: healthy participants, patients with chronic periodontitis, and patients with aggressive periodontitis. mRNA expression of IFN\u2010\u03bbs in gingival tissues was estimated using reverse transcriptase polymerase chain reaction and was correlated with clinical parameters such as gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>mRNA of IFN\u2010\u03bb1, IFN\u2010\u03bb2, and IFN\u2010\u03bb3 was expressed in gingival tissues of healthy participants and in patients with chronic or aggressive periodontitis. The highest level of IFN\u2010\u03bb1 was observed in patients with aggressive periodontitis (3.049 \u00b1 9.793), whereas IFN\u2010\u03bb2 (4.322 \u00b1 11.310) and IFN\u2010\u03bb3 (11.932 \u00b1 27.479) were highest in patients with chronic periodontitis. The difference in mRNA expression of IFN\u2010\u03bb1 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008) and IFN\u2010\u03bb3 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) among three groups was statistically significant<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased quantity of IFN\u2010\u03bbs in patients with chronic and patients with aggressive periodontitis suggests a role in periodontitis. Variation in the expression of IFN\u2010\u03bb1 and IFN\u2010\u03bb3 in patients with periodontitis needs to be further evaluated. The mRNA expression of antiviral IFN\u2010\u03bbs in gingival tissues might enhance our understanding related to viral pathogenesis of periodontal diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0349","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T03:55:23Z","timestamp":1525406123000},"page":"867-874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["mRNA expression of IFN\u2010\u03bbs in the gingival tissue of patients with chronic or aggressive periodontitis: A polymerase chain reaction study"],"prefix":"10.1002","volume":"89","author":[{"given":"Shivaprasad","family":"Bilichodmath","sequence":"first","affiliation":[{"name":"Department of Periodontology Rajarajeswari Dental College and Hospital  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sruthi K.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Periodontology Rajarajeswari Dental College and Hospital  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rekha","family":"Bilichodmath","sequence":"additional","affiliation":[{"name":"Department of Periodontology Rajarajeswari Dental College and Hospital  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin B.","family":"Mangalekar","sequence":"additional","affiliation":[{"name":"Deparment of Periodontology Bharti Vidyapeeth Dental College Wanlesswadi  Sangali Maharashtra 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