{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:25:03Z","timestamp":1783571103903,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"HOSODA SHC"},{"name":"Alpha Omega Foundation of Canada"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Products of internal defense systems, like pro\u2010inflammatory cytokines, reactive oxygen species, and leukocytes, are released which attack periodontal bacteria in periodontitis, but at the same time, lead to tissue destruction as well. We hypothesize that resveratrol derivative\u2010rich melinjo seed extract (MSE), an edible plant extract that has antioxidant properties, should promote healing of periodontal bone loss and modulating immune\u2010inflammatory systems that leads periodontal tissue destruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used an experimentally induced periodontitis (EP) model in mice. Ligatures were placed first for development of EP (15 days). MSE was intraperitoneally administrated (0.001% (w\/w)) to reverse bone loss that had already occurred in established EP and mice were then sacrificed (day 17, 20 and 22).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Morphometric outcomes revealed lower bone\u2010loss in the MSE groups compared to control. Immunohistochemistry assays demonstrated lower oxidative stress in MSE groups. MSE also inhibited M\u2010CSF\/sRANKL mediated osteoclast formation and down\u2010regulated osteoclast activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with MSE in EP actually caused healing of bone, and these effects are probably related to decreases in local oxidative damage and osteoclast activity. Given MSE's positive effects on osteodifferentiation as well, these findings suggest that MSE could be a useful therapeutic agent for the management of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0352","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T07:16:39Z","timestamp":1518246999000},"page":"586-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Resveratrol derivative\u2010rich melinjo seed extract induces healing in a murine model of established periodontitis"],"prefix":"10.1002","volume":"89","author":[{"given":"Eri","family":"Ikeda","sequence":"first","affiliation":[{"name":"Matrix Dynamics Group Faculty of Dentistry University of Toronto  Toronto ON Canada"},{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Matrix Dynamics Group Faculty of Dentistry University of Toronto  Toronto ON Canada"},{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Matrix Dynamics Group Faculty of Dentistry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Fine","sequence":"additional","affiliation":[{"name":"Matrix Dynamics Group Faculty of Dentistry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Matrix Dynamics Group Faculty of Dentistry University of Toronto  Toronto ON Canada"},{"name":"Lunenfeld\u2010Tanenbaum Research Institute (Mt. Sinai Hospital)  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Viniegra","sequence":"additional","affiliation":[{"name":"Matrix Dynamics Group Faculty of Dentistry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriyah","family":"Barzilay","sequence":"additional","affiliation":[{"name":"Matrix Dynamics Group Faculty of Dentistry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ganss","sequence":"additional","affiliation":[{"name":"Matrix Dynamics Group Faculty of Dentistry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard C.","family":"Tenenbaum","sequence":"additional","affiliation":[{"name":"Department of Dentistry Mount Sinai Hospital Centre for Advanced Dental Research and Care Toronto  ON Canada"},{"name":"Department of Laboratory Medicine and Pathobiology Faculty of Medicine Mount Sinai Hospital  Toronto ON Canada"},{"name":"Department of periodontology Faculty of Dentistry University of Toronto  Toronto ON Canada"},{"name":"Department of Periodontics School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Glogauer","sequence":"additional","affiliation":[{"name":"Matrix Dynamics Group Faculty of Dentistry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-008-0128-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.66"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100508"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.01.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/615486"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2165"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3662"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(00)01814-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2000.tb00325.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1989.tb00626.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.04.028"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2010.03.003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9728.2004.00097.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/851267"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(01)00158-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2012.665108"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0026-895X(24)12541-2","article-title":"Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity","volume":"56","author":"Casper RF","year":"1999","journal-title":"Mol Pharmacol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.916"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1670183"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.05.011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf803077p"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300841v"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120746"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.07.034"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.131"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071013"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(97)00035-5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-265744"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01461.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2325"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2798"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12221"},{"key":"e_1_2_8_38_1","first-page":"1","article-title":"Resveratrol Inhibits Periodontitis\u2010Related Bone Loss in Rats Submitted to Cigarette Smoke Inhalation","author":"Ribeiro FV","year":"2017","journal-title":"J Periodontol"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.10.031"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1211\/002235702612"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf4048435"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080233"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.1.403"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00162-3"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.2.275"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.09.053"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.11.003"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJPER.17-0352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.17-0352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:21:25Z","timestamp":1760869285000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.17-0352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/JPER.17-0352"],"URL":"https:\/\/doi.org\/10.1002\/jper.17-0352","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"2017-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}