{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:01:33Z","timestamp":1788843693358,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25253104"],"award-info":[{"award-number":["25253104"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A number of studies have suggested a bidirectional relationship of periodontitis with rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). However, the genetic factors that underlie these relationships have not been elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter case\u2010control study that included 185 patients with RA and chronic periodontitis (CP), 149 patients with T2DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults to assess the shared genetic risk factors for RA and CP as well as for T2DM and CP. A total of 17 candidate single nucleotide polymorphisms (SNPs) associated with RA, T2DM, and CP were genotyped.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple logistic regression analyses revealed that the <jats:italic>KCNQ1<\/jats:italic> rs2237892 was significantly associated with comorbidity of RA and CP (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) after adjustment for age, sex, and smoking status. The carriers of the T allele among patients with RA and CP showed significantly higher disease activity scores including 28 joints using C\u2010reactive protein values than the non\u2010carriers (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), although the age, female percentage, and smoking status were comparable. Other SNPs were not associated with comorbidity of RA and CP, T2DM and CP, or susceptibility to CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of the present pilot study suggest for the first time that the <jats:italic>KCNQ1<\/jats:italic> rs2237892 may constitute a shared genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0412","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T08:04:59Z","timestamp":1519286699000},"page":"315-324","source":"Crossref","is-referenced-by-count":11,"title":["The <i>KCNQ1<\/i> gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case\u2010control study"],"prefix":"10.1002","volume":"89","author":[{"given":"Tetsuo","family":"Kobayashi","sequence":"first","affiliation":[{"name":"General Dentistry and Clinical Education Unit Niigata University Medical and Dental Hospital"},{"name":"Division of Periodontology Niigata University Graduate School of Medical and Dental Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010ichi","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Endodontology Institute of Biomedical Sciences Tokushima University Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry Endodontology and Periodontology School of Dentistry Matsumoto Dental University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Omori","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Endodontics Okayama University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Niigata Rheumatic Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takato","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Aichi Gakuin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Bando","sequence":"additional","affiliation":[{"name":"Department of Dentistry Kawashima Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Nephrology Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Murasawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Niigata Rheumatic Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Nakazono","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Niigata Rheumatic Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Mitani","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Aichi Gakuin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Takashiba","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2010Periodontal Science Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Endodontology Institute of Biomedical Sciences Tokushima University Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Yoshie","sequence":"additional","affiliation":[{"name":"Division of Periodontology Niigata University Graduate School of Medical and Dental Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00425.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.28"},{"issue":"14","key":"e_1_2_8_5_1","first-page":"S113","article-title":"Lalla. 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