{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:21:28Z","timestamp":1787509288935,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Growing evidence suggests that oxidative stress forms a key component in the etiopathogenesis of periodontitis. Studies have shown potential antioxidants responsible for combating the pro\u2010oxidants which stress the periodontium. But, peroxiredoxin\u2010sulfiredoxin system is the least explored in periodontal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2010control study was conducted on 30 participants who fulfilled the inclusion criteria from the Department of Periodontics, Saveetha Dental College and Hospital, Chennai, India. The patients were divided into two groups: 1) Group A\u2010 healthy controls (n\u00a0=\u00a018), 2) Group B\u2010 patients with generalized chronic periodontitis (n\u00a0=\u00a017). Following clinical examination, gingival tissue samples were procured from both the groups and subjected to protein quantification by Lowry method. The samples with adequate protein concentration (n\u00a0=\u00a030) from the two groups were further analyzed by enzyme\u2010linked immunosorbent assay for estimation of sulfiredoxin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sulfiredoxin levels were significantly higher in the gingival tissues of chronic periodontitis patients (171.20\u00a0\u00b1\u00a016.97\u00a0ng\/mL) than in healthy controls (131.20\u00a0\u00b1\u00a022.87) with\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001. Also, the levels of sulfiredoxin in gingival tissue of periodontitis patients positively correlated with site\u2010specific probing depth (r\u00a0=\u00a00.67;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007) and clinical attachment level (r\u00a0=\u00a00.55;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.035).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study was a novel attempt to estimate the levels of sulfiredoxin which was significantly elevated in the diseased sites of patients with chronic periodontitis. Future studies are required to probe the role of sulfiredoxin in the etiopathogenesis of periodontal disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.17-0445","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T11:54:20Z","timestamp":1532519660000},"page":"1241-1248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":221,"title":["Comparative estimation of sulfiredoxin levels between chronic periodontitis and healthy patients \u2013 A case\u2010control study"],"prefix":"10.1002","volume":"89","author":[{"given":"Asha","family":"Ramesh","sequence":"first","affiliation":[{"name":"Department of Periodontics Saveetha Dental College and Hospital Saveetha University  No 162, Poonamallee High Road, Vellappanchavadi Chennai 600077"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheeja","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Periodontics Saveetha Dental College and Hospital Saveetha University  No 162, Poonamallee High Road, Vellappanchavadi Chennai 600077"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadathur D.","family":"Jayakumar","sequence":"additional","affiliation":[{"name":"Department of Periodontics Saveetha Dental College and Hospital Saveetha University  No 162, Poonamallee High Road, Vellappanchavadi Chennai 600077"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankari","family":"Malaiappan","sequence":"additional","affiliation":[{"name":"Department of Periodontics Saveetha Dental College and Hospital Saveetha University  No 162, Poonamallee High Road, Vellappanchavadi Chennai 600077"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"235","article-title":"Pathogenesis of inflammatory periodontal disease. A summary of current work","volume":"34","author":"Page RC","year":"1976","journal-title":"Lab Investig J Tech Methods Pathol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-775720140259"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329672"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92211-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2650659"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2000.90771.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2118682"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.4.557"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504398102"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070056"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130654"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2712"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091541"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002380"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.09.002"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.08.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00818.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.137938"},{"key":"e_1_2_8_22_1","first-page":"255","article-title":"Lipid peroxidation and antioxidant status in patients with periodontitis","volume":"10","author":"Panjamurthy K","year":"2005","journal-title":"Cell Mol Biol Lett"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2010.40.4.164"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.03.039"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05648.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02646.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.07.002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.10.001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.10.026"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.05.024"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2013.10.001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6943"},{"key":"e_1_2_8_37_1","first-page":"5196","article-title":"Identification of Nrf2\u2010regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray","volume":"62","author":"Thimmulappa RK","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_8_38_1","first-page":"1139","article-title":"Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases\u20103","volume":"54","author":"Sun Y","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.10.006"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.06.038"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.126839"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706420200"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01123.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00669.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.02.002"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3662"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.08.005"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1978.49.8.406"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJPER.17-0445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.17-0445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:41:03Z","timestamp":1760877663000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.17-0445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/JPER.17-0445"],"URL":"https:\/\/doi.org\/10.1002\/jper.17-0445","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]},"assertion":[{"value":"2017-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}