{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:28:22Z","timestamp":1760920102210,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the association between HLA\u2010B57.01 (Human leukocyte antigen) and clinical parameters of chronic periodontitis in people living with HIV (PLWHIV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients were recruited from the HIVCENTER at the University Hospital Frankfurt during April 2014 and July 2015. Periodontal examination included Periodontal Screening Index (PSI), Gingivalindex (GI), Bleeding on Probing Index (BOP), Periodontal Probing Depth (PD), Clinical Attachment Level (CAL) and DMF\u2010T Score (decayed, missing, filled teeth). Associations among periodontitis, HLA\u2010system and additional risk factors in PLWHIV were evaluated in multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred PLWHIV were enrolled. Forty\u2010five patients were naive, meaning that these patients never took antiretroviral (ARV) drugs before, 55 patients treated with combined antiretroviral therapy (cART). Nineteen patients presented a positive HLA\u2010B 57.01 status. PLWHIV who were carriers of HLA\u2010B 57.01 had significantly lower PSI\u2010scores (Grade 3 or higher; 0\/19 [0%] versus 16\/41 [39%] versus 17\/40 [42%]; <jats:italic>p\u00a0<\/jats:italic>=\u00a0&lt;\u00a00.001), GI\u2010scores (Grade 2 or higher; 0\/19 [0%] versus 19\/41 [46%] versus 28\/40 [70%]; <jats:italic>p\u00a0<\/jats:italic>=\u00a0&lt;\u00a00.001) and BOP\u2010Scores (2\/19 [1%] versus 38\/41 [92%] versus 40\/40 [100%]; <jats:italic>p\u00a0<\/jats:italic>=\u00a0&lt;\u00a00.001) in comparison to naive PLWHIV and PLWHIV receiving cART, who were both not carriers of HLA\u2010B 57.01. A lower value of PSI\u2010, GI\u2010 and BOP\u2010Score is associated with improved periodontal health. The adjusted odds ratio (OR) of periodontitis was decreased in patients who were carriers of HLA\u2010B 57.01 by measurement of PSI\u2010Score (OR\u00a0=\u00a00.006, 95% confidence interval (CI)\u00a0=\u00a00.001 to 0.026), GI\u2010Score (OR\u00a0=\u00a00.018, 95% confidence interval (CI)\u00a0=\u00a00.003 to 0.104) and BOP\u2010Score (OR\u00a0=\u00a00.003, 95% confidence interval (CI)\u00a0=\u00a0&lt;\u00a00.001 to 0.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HLA\u2010B 57.01 is an independent resistance indicator for generalized periodontitis in PLWHIV with respect to established cofactors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0532","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T14:22:02Z","timestamp":1525875722000},"page":"966-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["HLA\u2010B57.01 shields people living with HIV for significantly better periodontal health"],"prefix":"10.1002","volume":"89","author":[{"given":"Gundolf","family":"Schuettfort","sequence":"first","affiliation":[{"name":"University Hospital Frankfurt, J.W. Goethe\u2010University Department for Infectious Diseases, Internal Medicine II  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"de Leuw","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt, J.W. Goethe\u2010University Department for Infectious Diseases, Internal Medicine II  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Haberl","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt, J.W. Goethe\u2010University Department for Infectious Diseases, Internal Medicine II  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Herrmann","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt, J.W. Goethe\u2010University Department for Biostatistics and Mathematical Modelling  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu\u2010Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Taunadent Private practice  Oberursel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Wolf","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt, J.W. Goethe\u2010University Department for Infectious Diseases, Internal Medicine II  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Stephan","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt, J.W. 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